The Impact of Using Cold Irrigation on Postoperative Endodontic Pain and Substance P Level: a Randomized Clinical Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Post Operative Pain
- Sponsor
- Ain Shams University
- Enrollment
- 135
- Locations
- 1
- Primary Endpoint
- Level of post operative pain
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The aim of this clinical trial is to evaluate the effect of using intra-radicular cryotherapy technique in the form of irrigation with cold sodium hypochlorite
The main questions to answer are:
- Does Postoperative pain is different between the three groups?
- Does level of substance P different between the three groups ?
Detailed Description
* The patients will be randomly divided into three groups Group 1: control group (n=25) Regular root canal treatment with regular irrigant will be used. Group 2: (n=25) Intraradicular cryotherapy will be performed where : * Normal root canal treatment will be done with irrigation using sodium hypochlorite cooled to 2°C continuously during our mechanical instrumentation. Then a final flush will be done with cold saline 2°C for 5 minutes. Group 3: (n=25) Normal root canal treatment will be done with irrigation using sodium hypochlorite at room temperature during our mechanical instrumentation. Then a final flush will be done with cold saline 2°C for 5 minutes.
Investigators
Maram Obeid
Professor of Endodontics
Ain Shams University
Eligibility Criteria
Inclusion Criteria
- •Patients that will be diagnosed with symptomatic apical periodontitis
- •Single-rooted premolars (radiographically and clinically assessed)
- •Medically free patients.
- •Teeth with mature apex
Exclusion Criteria
- •Patients with other pulpal diagnosis.
- •Medically compromised patients.
- •Pregnant females.
- •Patients taking analgesics or anti-inflammatory drugs.
Outcomes
Primary Outcomes
Level of post operative pain
Time Frame: after 6 hours, 24 hours, 48 hours, 72 hours
On visual analogue scale (VAS) questionnaire, patients will report their level of pain 0° refers for no pain, and the 100° degree refers for unbearable pain
Secondary Outcomes
- Level of substance P(After access cavity, after finishing mechanical perpetration, before obturation(after 3 days))