FLT3 Gene Mutations among Acute Myeloid Leukemia patients in Northeast Thailand

Completed

• Conditions: ewly diagnosed acute myeloid leukemia patients; FLT3-ITD, FLT3-TKD, Acute myeloid leukemia, newly-diagnosed AML; FLT3-ITD, FLT3-TKD, Acute myeloid leukemia, newly-diagnosed AM

• Registration Number: TCTR20220928006
• Lead Sponsor: /A

Brief Summary

Frequencies of FLT3-ITD and TKD were found to be 16.9% (11/65) and 10.8% (7/65), respectively. The WBC and peripheral blast percentage of FLT3-ITD positive patients were statistically significantly higher than those of the FLT3-wild type patients, while the peripheral blast percentage of FLT3-TKD positive patients was significantly lower. No other clinical characteristics among FLT3 positive and FLT3-wild type patients were observed.DNA sequencing identified 4 FLT3-TKD mutations.

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-05-31
• Study Start: 2022-09-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

all newly diagnosed AML patients between January 2020 and May 2021

Exclusion Criteria

N/A

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
FLT3-ITD and FLT3-TKD at the beginning of study PCR based method

Secondary Outcome Measures

Name	Time	Method
/A N/A N/A