Surgical Trial in Lobar Intracerebral Haemorrhage

ewcastle upon Tyne Hospitals NHS Trust (UK)0 个研究点目标入组 600 人开始时间: 2006年10月11日最近更新: 2023年5月22日

适应症

试验速览

2011 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/21586127 protocol 2013 Results article in http://www.ncbi.nlm.nih.gov/pubmed/23726393 results 2018 Other publications in https://www.ncbi.nlm.nih.gov/pubmed/29321340 retrospective methods analysis 2023 Other publications in https://pubmed.ncbi.nlm.nih.gov/37161757/ (added 10/05/2023)

•1. Evidence of a spontaneous lobar ICH on Computed Tomography (CT) scan (within 1 cm of the cortical surface)
•2. Patient within 48 hours of ictus
•3. The 'clinical uncertainty principle' is used: only patients for whom the responsible neurosurgeon is uncertain about the benefits of either treatment are eligible. These include patients with a haematoma volume of between 10 and 100 ml and a best motor score on the Glasgow Coma Score (GCS) of five or six together with some eye opening

•1. Clear evidence that the haemorrhage is due to an aneurysm or angiographically proven arteriovenous malformation
•2. Intraventricular haemorrhage of any sort
•3. ICH secondary to tumour or trauma
•4. Basal ganglia, thalamic, cerebellar or brainstem haemorrhage or extension of a lobar haemorrhage into any of these regions
•5. Severe pre-existing physical or mental disability or severe co-morbidity which might interfere with assessment of outcome
•6. If surgery cannot be performed within 12 hours

发起方

ewcastle upon Tyne Hospitals NHS Trust (UK)