Identification of psychometric and biological markers to assess androgen and serotonergic sensitivity in relation to sexual functioning in women.

Completed

Conditions: Female Sexual Dysfunction
Hypoactive Sexual Desire Disorder
10013356

Registration Number: NL-OMON34558

Lead Sponsor: Emotional Brain

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

1. Provision of written informed consent;
2. Female 21-70 years of age;
3. Healthy according to normal results of medical history
4. Subject must be heterosexually oriented;
5. BMI >= 18 and <= 30 kg/m2;
6. Dutch as first language;

Exclusion Criteria

1. Subjects who have had hand surgery interfering with measurement of digit lengths;
2. Subjects with musculoskeletal conditions affecting the measurements of digit lengths;
3. Known conditions associated with abnormal prenatal androgen exposure, namely congenital adrenal hyperplasia and complete androgen insensitivity syndrome;
4. Positive drug test and/or positive alcohol test;
5. Subjects with dyslexia;
6. Subjects who are color-blind;
7. Positive urine pregnancy test;
8. Use of oral contraception containing anti-androgens (e.g. Diane 35; Minerva);
9. Use of oral contraception containing 50 µg estrogen or more;
10. Homosexual orientation.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. [CAG]n<br /><br>2. Calculated second to fourth digit ratio<br /><br>3. Pre-attentional bias for erotic stimuli (Stroop task)<br /><br>4. Blood serum free testosterone levels</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Blood serum levels ADT-G, 3a-diol-G, DHEA and DHEA(s)<br /><br>2. Genotype SERT and 5HT1a receptor<br /><br>3. Questionnaires: SAQ, SSEQ and SMQ</p><br>