A randomised, controlled trial in primary care of a nicotine replacement therapy (NRT) assisted cessation intervention amongst adult smokers with established vascular disease to confirm effectiveness, safety and genetic influences

niversity of Oxford (UK)0 个研究点目标入组 2,400 人开始时间: 2005年4月1日最近更新: 2015年1月13日

适应症

试验速览

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•All smokers (self-report =10 cigarettes per day) aged 18 years and over who wish to stop with (at least) one of the following diagnoses:
•1. Ischaemic Heart Disease:
•i. Stable Angina, clinically or exercise electrocardiogram (ECG) diagnosed
•ii. Myocardial infarction more than 2 months previously with recovery uncomplicated by any rhythm disturbances other than atrial fibrillation
•2. Cerebrovascular disease: No exclusions
•3. Peripheral vascular disease: No exclusions

•1. Patients the GP, for whatever reason, does not wish to include
•2. Known skin hypersensitivity to nicotine, plasters or widespread active eczema/psoriasis or other skin conditions that would restrict patch application
•3. Pregnant or breast feeding women or those who are not using reliable contraceptive methods
•4. Phaeochromocytoma/Hyperthyroidism and severe renal and/or hepatic impairment
•5. Severe (life threatening) arrhythmia
•6. Command of English (+/- interpreter) or impairment of faculties does not allow informed consent

发起方

niversity of Oxford (UK)