Feasibility and Preliminary Data on the Interplay Between Oxytocin and Cortisol During Stress in Borderline Personality Disorder
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Salivary cortisol
Study Overview
Brief Summary
This study aims to determine the feasibility and preliminary data on the interaction between oxytocin and cortisol during stress in borderline personnality disorder.
Detailed Description
The investigators will recruit 50 female patients with borderline personnality disorder and 50 controls with no psychiatric diagnosis, aged between 18 and 25 years old.
salivary cortisol daily curve ( 6 measures during the day) will be measured in participant's naturalistic environnement, together with salivary oxytocin. In addition, salivary oxytocin and cortisol will be measured during a psychosocial stress task and recovery.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Borderline personality disorder-DSM V
Exclusion Criteria
- •Schizophrenia
Outcomes
Primary Outcomes
Salivary cortisol
Time Frame: Change during experimental task (up to 2 hours)
salivary cortisol measured with salivettes (swabs)
Salivary oxytocin
Time Frame: Change during experimental task (up to 2 hours)
salivary oxytocin measured with salivettes (swabs)
Secondary Outcomes
No secondary outcomes reported
Investigators
Tatiana Aboulafia Brakha
PhD
University of Geneva, Switzerland