Effect of growth hormone on muscle functio

Not Applicable

Completed

• Conditions: Growth hormone deficiency; Metabolic and Endocrine - Normal metabolism and endocrine development and function

• Registration Number: ACTRN12615000046505
• Lead Sponsor: Princess Alexandra Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-01-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Growth hormone deficiency (diagnosed as per internationally accepted criteria)

Exclusion Criteria

1.Cardiac, respiratory, renal, liver or neurological disease
2.Pregnancy
3.Malignancy
4.Inability to consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Anaerobic Capacity was assessed by a 30-second all out sprint on a cycle ergometer during the Wingate test<br>[At baseline and at 1, 2 and 8 months ];Aerobic capacity was measured as VO2max during an incremental exercise test on a cycle ergometer<br><br>[At baseline and at 1, 2 and 8 months ]

Secondary Outcome Measures

Name	Time	Method
Chair-stand test. This measures the number of chair-stand repetitions during 30 seconds<br><br>[At baseline and at 1, 2 and 8 months ];Stair-climb test. This measures the time taken to climb 4 flights of stairs.<br><br>[At baseline and at 1, 2 and 8 months ];7-day Pedometry. This measures the number of step counts over 7 days by a pedometer. <br>[At baseline and at 1, 2 and 8 months ];Metabolic gene expression in skeletal muscle.<br><br>This will be undertaken by studying genes regulating energy metabolism by microarray analysis of biopsies of quadriceps muscle[At 1, 2 and 8 months ];Body composition assessed by DEXA scan<br>[At baseline and at 1, 2 and 8 months ]