Evaluating the effects of tourniquet use in total knee arthroplasty
- Conditions
- Knee osteoarthritisKnee arthroplastyMusculoskeletal - OsteoarthritisSurgery - Surgical techniques
- Registration Number
- ACTRN12618000425291
- Lead Sponsor
- Barwon Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 90
1.undergoing primary total knee replacement for primary osteoarthritis
2.> 18 years of age
3.Willing, able and mentally competent to provide informed consent
1.Undergoing bilateral total knee replacement
2.Neurological deficit affecting operated knee
3.Rheumatoid arthritis
4.Pre-operative knee flexion <60 (degree of flexion required for strength testing)
5.Varus/valgus deformity > 15
6.Opioid tolerant (current use of oxycontin, opioid patches, or tramadol; >4 tabs panadeine forte per day)
7.Sulphonamide allergy (to allow parecoxib/celecoxib use)
8.Intolerant/allergic to oxycodone
9.Poorly controlled diabetes (HbA1C >8) (impacts on choice of dexamethasone as antiemetic)
10.Cognitively impaired (mini-mental state examination of <25/30 [18])
11.eGFR < 60 mL/min/1.73m2 (to allow parecoxib/celecoxib use)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Isometric quadriceps strength will be measured in Newtons and assessed by a trained research assistant using a fixed-base electromechanical dynamometer (IsoForceControl EVO2 dynamometer) with the knee stabilised in 60 degrees of flexion. Patient will be seated in a customised chair with a frame to fix the dynamometer in position. Following 1-2 practices, participants will extend their knee as forcefully as they can for 10 seconds. The maximum force from three consecutive attempts will be recorded.[3 months post-operatively]
- Secondary Outcome Measures
Name Time Method