A Study comparing nebulised Amphotericin B with oral itraconazole for treatment of complex aspergilloma patients attending a tertiary care hospital

Intramural project of AIIMS New Delhi0 个研究点目标入组 32 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1)Patients having pulmonary aspergilloma on Computed tomography thorax with symptoms like cough, hemoptysis etc.
•2)Age more than 18 years
•3)Patients not having other concomitant respiratory infections

•1)Patients having severe constitutional features like high grade fever, massive hemoptysis etc.
•2)Patients who have hypersensitivity to either azoles or Amphotericin B.
•3)Patients not giving consent for bronchoscopic intervention or receiving nebulised Amphotericin B
•4)overt immunosuppressive state (patients on immunosuppressive drugs, intake of prednisolone (or equivalent) >10 mg for at least 3 weeks, uncontrolled diabetes mellitus and others),
•5)Invasive aspergillosis, ABPA, CNPA, active pulmonary tuberculosis or malignancy
•6) Pregnancy
•7)Patient who are not anti-fungal naÃ¯ve (who has received antifungals through oral or iv route for more than 7 days in the last 6 months)

发起方

Intramural project of AIIMS New Delhi