Cardiopulmonary Bypass Ischemia/Reperfusion Injury and Postoperative Multiple Organ Dysfunction in Elder Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Complications
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- incidence of postoperative cardiac injury
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of the study is to identify the correlation between ischaemia reperfusion injury and postoperative multiorgan damage during cardiopulmonary cardiac surgery; and to investigate biomarkers that can predict postoperative organ damage in cardiac surgery.
Detailed Description
This study proposes to observe multi-organ functional impairment of the heart, kidney and brain after extracorporeal circulation in a prospective study of clinical patients; to obtain markers with diagnostic and predictive efficacy by collecting pre and postoperative serum and heart and ear tissue samples from patients with postoperative organ functional impairment, performing combined proteomic and metabolomic analyses, and by analysing them with detailed postoperative clinical prognostic data using machine learning algorithms.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age ≥50 years; patients requiring mitral valve replacement surgery or mitral valve plus aortic valve replacement under cardiopulmonary bypass
- •Agreed to participate in this study, and signed the informed consent form.
Exclusion Criteria
- •History of neurological disease (stroke, reversible ischemic hypoxia, transient ischemic attack, or Neurodegeneration) ;
- •Patients with severe preoperative renal insufficiency (serum creatinine \> 442 μmol/L or need renal replacement therapy) ,
- •liver dysfunction (Child-Pugh grade C)
- •myocardial infarction within 4 weeks
- •ASA grade ≥ V
Outcomes
Primary Outcomes
incidence of postoperative cardiac injury
Time Frame: from the ending of surgery to 7 days after surgery
troponin I will be tested before and after surgery
incidence of postoperative brain injury
Time Frame: from the ending of surgery to 7 days after surgery
deliriumwill be tested before and after surgery
incidence of postoperative acute kidney injury
Time Frame: from the ending of surgery to 7 days after surgery
renal function will be tested before and after surgery
Secondary Outcomes
- Incidence of postoperative arrhythmia events(from the ending of surgery to 72 hours after surgery)