Ticagrelor of prasugrel versus clopidogrel bij ouderepatiënten met een acuut coronair syndroom (pijn op deborst en hartinfarct) en een hoog bloedingsrisico:Optimaliseren van bloedplaatjes remming bij ouderenmet verhoogd bloedingsrisico
- Conditions
- Anti-platelet therapy in the elderly with Non ST elevation acute coronary syndrome and CRUSADE score of at least 31
- Registration Number
- NL-OMON21629
- Lead Sponsor
- St. Antonius teaching hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 1000
Inclusion Criteria
1) At least 75 years of age.
2) Hospitalization for NSTEMI or unstable angina (UA), according to the following definitions
NSTEMI (Non-ST-elevation myocardial infarction) will be defined as detection of a rise and/or fall of cardiac biomarker values [preferably cardiac troponin (cTn)] with at least one value above the 99th percentile upper reference limit (URL) and with at least one of the following:
Exclusion Criteria
Exclusion criteria
1)Contraindication to P2Y12 inhibitors i.e. clopidogrel, prasugrel or ticagrelor:
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The first primary endpoint is the occurrence of any bleeding episode at 30 days and 1 year after diagnosis and second primary endpoint is the net clinical benefit at 30 days and 1 year after diagnosis.
- Secondary Outcome Measures
Name Time Method