ASS-Nonresponse Following Cardiac Surgery as Assessed With Multiple Electrode Aggregometry
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ASS-Nonresponse
- Sponsor
- Goethe University
- Enrollment
- 400
- Locations
- 2
- Primary Endpoint
- ASPItest
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
It is the aim of the present study to assess the prevalence of ASS-Nonresponse following cardiac surgery using the Multiple Electrode Aggregometry (MEA).
Detailed Description
Up to now there are no data concerning the prevalence of ASS-Nonresponse following surgical coronary revascularization procedures as assessed with the Multiple Electrode Aggregometry. Results of the present observational study are needed to assess the prevalence of ASS-Nonresponse in order to perform a sample size analysis for a prospective interventional study in a second step.
Investigators
Christian F. Weber, MD
Dr.med. Dr.med. habil Christian F. Weber
Goethe University
Eligibility Criteria
Inclusion Criteria
- •Patients older than 18 years after cardiac surgery
- •Antiaggregatory therapy with aspirin postoperatively
Exclusion Criteria
- •known allergy to aspirin
- •need for an antiaggregatory therapy other than aspirin
- •pregnancy
Outcomes
Primary Outcomes
ASPItest
Time Frame: at day 3 and 5 after the first dose of aspirin following surgery
Area under the aggregation curve following stimulation with arachidonic acid in the Multiple Electrode Aggregometry (MEA)
Secondary Outcomes
- TRAPtest(at day 3 and 5 after the first dose of aspirin following surgery)
- Platelet Count(at day 3 and 5 after the first dose of aspirin following surgery)
- Myocardial infarction(12 month)
- Mortality(12 month)
- Readmission to hospital(12 month)