A prospective randomized controlled study to compare the efficacy of combined Axillary and Pectoral drainage versus Sole Axillary drainage in Modified Radical Mastectomy

Breast cancer has seen a rapid rise inincidence, becoming the leading cause of global cancer incidence in 2020.Choice of treatment is Modified Radical Mastectomy (MRM). Most commonlyencountered complication of MRM is formation of seroma, which can be preventedby the use of closed suction drainage system, preferable active suctiondrainage.

 ThisProspective Randomised controlled study attempts to compare the efficacy andthe morbidities associated with use of combined axillary and pectoral drainversus single axillary drainage post modified radical mastectomy.

Objectives:Assessing the incidence of seroma formation, post op wound infection, durationof drain insitu, drain output and length of hospital stay

 Womenwith histologically proven breast cancer, stage 1,2 3 not undergoingneoadjuvant therapy undergoing MRM, will be included in the study and will berandomized into 2 groups using envelope method, Group A (single axillary drain)and Group B (combined axillary and pectoral drainage), with 78 patients in eachgroup (total sample size 156)

 Standardizedoperative procedure and post-operative course will be followed in all patientsin both groups in drain emptying and dressing

Patient will be followed up postoperativelyto evaluate drain output, incidence of surgical site infection, flap necrosis,seroma formation (clinically and quantified with ultrasonography), timing ofdrain removal and total duration of hospital stay.

 Data willcollected and analyzed with SPSS version 28.

The quantitative data will be reported as meanand standard deviation. Differences between means will be tested with Student’st-test and the incidence of seroma, flap necrosis and wound infection will bereported as number and percentages and Fisher’s exact test/ Chi square testwill be employed.