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临床试验/NCT05371821
NCT05371821Unknown不适用

Cardiac Assessment of Obese and Overweight Children Attending Asyut University Children Hospital

Assiut University0 个研究点目标入组 50 人开始时间: 2022年5月20日最近更新:
适应症

试验速览

阶段
不适用
入组人数
50
主要终点
Assessment of body mass index

研究概览

简要总结

Is to assess cardiac functions of overweight and obese children attending assiut University children hospital in one year duration .

详细描述

The prevalence of overweight and obesity in children is increasing worldwide at an alarming rate in both developing and developed countries .the relation between obesity and cardiac structure and function in children is less well documented and conflicting results have been reported .In addition, obesity is associated with a heterogeneity of metabolic abnormalities , (e.g., dyslipidemia , insulin resistance hyperglycaemia and hypertension , that may provide a plausible biologic link between obesity and the increased risk of cardiovascular morbidity and mortality .The clustering of these risk factors for cardiovascular disease is referred to as the "metabolic syndrome." Although the concept and definition of the metabolic syndrome are controversial at the moment, there is no doubt that a cluster of cardiovascular risk factors is present in obese children and adolescents and that their presence increases with worsening obesity .children are likely to be the ideal candidates for providing insight into the myocardial changes related to obesity because they are suggested to be free of other cardiovascular risk factors indifferent echocardiographic studies .

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
2 Years 至 18 Years(Child, Adult)
性别
All
接受健康志愿者

入选标准

  • Age: children at 2-18 years .
  • Overweight children whose body mass index at or above the 85th percentile and below the 95th percentile for the same age and sex
  • Obese children whose body mass index at or above the 95th percentile for the same age and sex.

排除标准

  • 1- Obese children below two years 2 - Cases with syndromic obesity, diabetes
  • thyroid and parathyroid and those with congenital heart diseases

结局指标

主要结局

Assessment of body mass index

时间窗: baseline

BMI described in kg / m²

Cardiac assessment of obese and overweight children

时间窗: Baseline

Echocardiography performed by an expert cardiologist using a Philips envisor c machine to assess the following parameters (left ventricle end-diastolic diameter (LVEDD), left ventricle end-systolic diameter (LVESD), interventricular septal systolic diameter (IVSSD), interventricular septal diastolic diameter (IVSDD) left ventricle fraction shortening (FS), left ventricle ejection fraction (EF), left atrium to aorta ratio (LA:AO), mitral annular plane area systolic excursion (MAPSE), fraction area shortening of the right ventricle (FAC), tricuspid annular plane systolic excursion (TAPSE)

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Osman Gamal Hassan

Cardiac assessment of obese and overweight children attending Asyut University children hospital

Assiut University

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