Cardiac Assessment of Obese and Overweight Children Attending Asyut University Children Hospital
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity, Childhood
- Sponsor
- Assiut University
- Enrollment
- 50
- Primary Endpoint
- Assessment of body mass index
- Last Updated
- 3 years ago
Overview
Brief Summary
Is to assess cardiac functions of overweight and obese children attending assiut University children hospital in one year duration .
Detailed Description
The prevalence of overweight and obesity in children is increasing worldwide at an alarming rate in both developing and developed countries .the relation between obesity and cardiac structure and function in children is less well documented and conflicting results have been reported .In addition, obesity is associated with a heterogeneity of metabolic abnormalities , (e.g., dyslipidemia , insulin resistance hyperglycaemia and hypertension , that may provide a plausible biologic link between obesity and the increased risk of cardiovascular morbidity and mortality .The clustering of these risk factors for cardiovascular disease is referred to as the "metabolic syndrome." Although the concept and definition of the metabolic syndrome are controversial at the moment, there is no doubt that a cluster of cardiovascular risk factors is present in obese children and adolescents and that their presence increases with worsening obesity .children are likely to be the ideal candidates for providing insight into the myocardial changes related to obesity because they are suggested to be free of other cardiovascular risk factors indifferent echocardiographic studies .
Investigators
Osman Gamal Hassan
Cardiac assessment of obese and overweight children attending Asyut University children hospital
Assiut University
Eligibility Criteria
Inclusion Criteria
- •Age: children at 2-18 years .
- •Overweight children whose body mass index at or above the 85th percentile and below the 95th percentile for the same age and sex
- •Obese children whose body mass index at or above the 95th percentile for the same age and sex.
Exclusion Criteria
- •1- Obese children below two years 2 - Cases with syndromic obesity, diabetes
- •thyroid and parathyroid and those with congenital heart diseases
Outcomes
Primary Outcomes
Assessment of body mass index
Time Frame: baseline
BMI described in kg / m²
Cardiac assessment of obese and overweight children
Time Frame: Baseline
Echocardiography performed by an expert cardiologist using a Philips envisor c machine to assess the following parameters (left ventricle end-diastolic diameter (LVEDD), left ventricle end-systolic diameter (LVESD), interventricular septal systolic diameter (IVSSD), interventricular septal diastolic diameter (IVSDD) left ventricle fraction shortening (FS), left ventricle ejection fraction (EF), left atrium to aorta ratio (LA:AO), mitral annular plane area systolic excursion (MAPSE), fraction area shortening of the right ventricle (FAC), tricuspid annular plane systolic excursion (TAPSE)