Web-based Weight Loss Intervention
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Overweight and Obesity
- Sponsor
- 23andMe, Inc.
- Enrollment
- 63656
- Locations
- 1
- Primary Endpoint
- Change in weight from week 1 to week 12 of intervention
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Excess weight is a major risk factor underlying leading causes of death globally, including cardiovascular disease, type 2 diabetes, and some cancers. Among participants assigned to the same lifestyle intervention arms in prior weight loss randomized controlled trials, large inter-individual differences in weight loss success have been observed, ranging from >50lbs of weight loss to >10lbs of weight gain. Both genetic and non-genetic factors underlying differential adherence and weight loss success are poorly understood.
Detailed Description
23andMe aims to recruit 91,227 adults to participate in a web-based weight loss intervention. Primary aims include: a.) to confirm whether AG/GG individuals at MTIF3 rs1885988 lose more weight on lifestyle interventions; and b.) to test the performance of a randomized controlled trial vs. self-selection study design in terms of weight loss, drop-outs, and adherence. Secondary (exploratory) analyses will focus on discovery of genetic and non-genetic predictors of weight loss success overall, and examination of potential interactions by intervention type. Web-administered intervention content, videos, and forums will be surfaced to participants every two weeks, and self-reported surveys will be surfaced weekly for the active intervention duration.
Investigators
Eligibility Criteria
Inclusion Criteria
- •US-based men and women in self-reported 'good' or better health
- •Consented to participate in research
- •BMI 25-40 kg/m2
- •Not actively on a weight loss plan
- •Willing and able to modify eating and physical activity patterns
- •Not under a doctor's care for a serious medical condition
Exclusion Criteria
- •Are pregnant, lactating, within 6 months postpartum, or planning to become pregnant in the next 6 months
- •Have diabetes (type 1 or 2) or are on hypoglycemic medications
- •Had a heart attack or stroke within the past year
- •Are unable or unwilling to follow a physical activity or diet intervention due to a medical condition or doctor's orders
- •Have an eating disorder
- •Have severe depression, anxiety, or other psychiatric conditions
Outcomes
Primary Outcomes
Change in weight from week 1 to week 12 of intervention
Time Frame: 12 weeks
Secondary Outcomes
- Change in waist circumference from week 1 to week 12 of intervention(12 weeks)
- Change in waist-to-hip ratio from week 1 to week 12 of intervention(12 weeks)