Neuronal Correlates of Agency in Dystonia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 76
- 试验地点
- 2
- 主要终点
- agency tasks behavioral outcome measures
研究概览
简要总结
In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia:
(i) investigate various aspects of the sense of agency and relationship to the severity of dystonia symptoms, (ii) characterize the possible link between abnormalities of movement perception and alteration of sense of agency in dystonia, (iii) (identify the neuronal underpinnings of the defective sense of agency in dystonia.
详细描述
This is a single-centre, two-group ( dystonia and control), case-control study using behavioural and novel multimodal neuroimaging techniques to address the study aims.
The battery of the tasks will include explicit-agency tasks, a visual discrimination task on objects movement perception. The magnetic resonance acquisition protocol will include MP2RAGE structural (10 min duration), multi echo (3 echo times) multiband (MB factor 4) resting state functional neuroimaging (15 minutes duration) and multi shell diffusion imaging sequence (15 minutes duration)
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 15 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosis of isolated adult-onset cervical dystonia (CD) or myoclonus dystonia (MD);
- •duration of disease of more than one year
- •no botulinum toxin injection for at least three months before the study
- •normal or corrected-to-normal vision.
排除标准
- •any neurological history except for dystonia,
- •history of dopamine antagonist treatment,
- •secondary dystonia,
- •dystonia in the upper limbs,
- •inability to maintain gaze straight.
结局指标
主要结局
agency tasks behavioral outcome measures
时间窗: throughout study completion, an average 2 years
response time
次要结局
- MRI measures(throughout study completion, an average 2 years)