Effect of ayurveda interventions in the management of ‘Amavata’ with special reference to Rheumatoid Arthritis.
- Conditions
- Rheumatoid arthritis, unspecified. Ayurveda Condition: AMAVATAH,
- Registration Number
- CTRI/2022/05/042860
- Lead Sponsor
- National institute of ayurveda deemed to be university jaipur
- Brief Summary
**INTRODUCTION:**
***‘Amavata’*** as a separate disease entity was described for the first time in detail by *Acharya Madhav Kara (700 A.D.)* who devoted a full chapter of *Amavata* in his famous monograph *‘Madhava Nidana’.* He mentioned etiopathogenesis of *Amavata* in systemic manner besides the signs, symptoms, complications and prognosis. In *Brahtriya*, there is no description regarding *Amavata*as a separate disease entity.
The changing lifestyle of human being by means of dieteric and behavious pattern plays a major role in the manifestation of the disease *Amavata.* Though all the *Doshas*take part in the causation of this disease, *Ama and Vitiated vata* play the dominant role. *Amavata* is disease of *Rasavaha srotasa*and it is the outcome of *Agnidushti, Amotpatti and Sandhivikruti.*
First the disturbance in function of *Agni (Jatharagnimandya, dhatvagnimandya, bhutagnimandya and malasanchaya)* occurs in body and leads to formation of *Ama* in body. *Vitiated Vayu*circulates the *Ama*all over the body through *Dhamanis,* takes, which shelter in the *Shleshmasthana* (*Amashaya*, *Sandhi* etc.), producing symptoms like swelling, tenderness and stiffness in small and big joints. Here it mixes with *vata, pitta and kapha* acquires variative colours and becomes viscous. Due to this process, symptoms of *Amavata* such as *Daurbalya*, *Jadyata* and *Hridgaurava* occur1.
The symptoms of *Amavata* are identical to rheumatoid arthritis. It is an auto immune disorder which has significant parlance with *Amavata*. It is one of the common developing disease because of its chronicity and implications.
There are good numbers of drugs describes in *Ayurvedic* classics for the management of *Amavata*. The trial drugs selected for the study is:
· *Vaishwanara Churna* mentioned in *Bhaishajya Ratnavali**2* (29/ 48-51),
· *Sinhanada Guggulu**3* mentioned in *Ayurveda sara sangrah (guggulu prakaran)*and
· *Rasnasaptaka Kwatha* mentioned in *Bhaishajya Ratnavali**4* (29/ 25) in *Amavata Chikitsa*.
**NEED OF THE STUDY:**
Many people in society are unaware about this disease and its complications which is responsible for life long joint deformities. Many *Ayurvedic* preparations are mentioned in *Samhita* which are very effective in the treatment of *Amavata*. *Amavata*(rheumatoid arthritis) has been a challenging problem to the medical field. The lives of more than 1 million people are physically impaired by rheumatoid arthritis. Due to its wide prevalence of morbidity and lack of effective drugs, it is need of time to find out effective solution in the management of *Amavata* (rheumatoid arthritis).
A lot of research work has already been done on treatment of *Amavata* in both modern and Ayurveda sciences and lots of still going on. By looking into the above-mentioned facts, there is a need for a treatment which can prevent complication of the disease as well as improves quality of life of patients.
The treatment of *Amavata* is very expensive and modern medications have serious side effects also.Due to wide spectrum and much prevalence of the disease and lack of effective medical treatments, the disease is being chosen for the study.
The line of treatment described for the disease in *Ayurveda* is-**6**
**“****लंघनंसà¥à¤µà¥‡à¤¦à¤¨à¤‚तिकà¥à¤¤à¤‚दीपनानिकटूनिच****।**
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- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 30
- Patients willing to sign consent form for the clinical trial.
- Patients between the age group of 18 to 60 years, irrespective of sex and socio-economic status.
- Patients having signs and symptoms of ‘Amavata’ (Rheumatoid Arthritis) 4.
- Patients fulfill the criteria of ACR/ EULAR 2010 criteria (American College of Rheumatology/ European League Against Rheumatism) 5.
- Patients with chronicity of less than 5 years.
- Patients having severe joint deformities.
- Patients suffering from paralysis.
- Patients having any type of arthropathy such as Neoplasm of spine, Gout, Ankylosing spondylosis, Traumatic arthritis and Pyogenic osteomyelitis etc.
- Patients having associated Cardiac disease, Tuberculosis, Diabetes mellitus, Malignant Hypertension, Renal Function Impairment, Hypothyroidism, Rheumatic Heart Disease etc.
- Patients with extremely reduced joint space.
- Pregnant women and lactating mother.
- Patient taking disease modifying anti-rheumatic drugs (DMARDs) for rheumatoid arthritis.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in DAS- 28 score. 56 Days
- Secondary Outcome Measures
Name Time Method Changes in symptoms of Amavata, Improvement in quality of life and changes in CRP, RA Factor, Disability Index Score, other symptoms, Improvement in walking time, hand & foot grip. 56 Days
Trial Locations
- Locations (1)
National institute of ayurveda deemed to be university jaipur
🇮🇳Jaipur, RAJASTHAN, India
National institute of ayurveda deemed to be university jaipur🇮🇳Jaipur, RAJASTHAN, IndiaDr Nikita SharmaPrincipal investigator8741097165niksharma1641996@gmail.com