Characterization of Ascending and Descending Auditory Processing Involved in the Encoding of Speech Sounds in Adult and Children: Variability Related to Changes in Sensory Input or a Neurodevelopmental Disorder or Targeted Remediation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Change from Baseline speech auditory brainstem and late responses (composite and objective measure) in response to syllables (behavioral measure)
研究概览
简要总结
The ability to encode the speech signal is determined by ascending and descending auditory processing. Difficulties in processing these speech signals are well described at the behavioral level in a specific language disorder. However, little is known about the underlying pathophysiological mechanisms. The assumption is that we should observe a degradation of the signal provided by the ear in the deaf subject while in case of specific language impairment it would be a phonemic disorder (possibly linked to a processing disorder auditory). The two population groups should therefore have different abnormalities of their central auditory process - which could be modified by the target remediation for each group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For all subjects:
- •native French speaker
- •no medical treatment for behavior or neurological disorders
- •normal or corrected vision
- •right-handed
- •normal otorhinolaryngology examination
- •valid affiliation to social security
- •no participation to another research study
- •For the normal-hearing subjects
- •normal tonal hearing thresholds
- •normal tympanometry
- •For the subjects without specific language impairment
- •aged from 6 ro 40
- •normal school attendance without scholastic retardation
- •normal intellectual level
- •normal for age reading skills
- •no delayed speech (expression & production)
- •For the children with specific language impairment
- •aged fom 8 to 18
- •persistent specific literacy difficulties with reading levels at least 18 months behind that of their peers
- •normal intellectual level
- •For the hearing impaired subjects
- •age from 18 to 70
- •first auditory rehabilitation
- •bilateral and symmetric hearing loss (±10 dB) with hearing thresholds between 0 and 25 dB at 0.25 kilohertz, 0 and 35 dB at 0.5 kilohertz, 0 and 50 dB at 1 kilohertz, 25 and 70 dB at 2 kilohertz, 25 and 80 dB at 3 kilohertz, 30 and 80 dB at 4 kilohertz
排除标准
- •non signed assent
- •treatment for depression, epilepsy, Parkinson's or alzheimer's disease during more than 6 months
- •physical health deficiency
- •mental retardation
- •neurological or psychiatric disease incompatible with testing procedure
- •For children
- •known problem of hearing loss or chronic middle ear disease whic compromized the hearing status
- •schooling in a foreign language
- •foreign language spoken at home with both parents
研究组 & 干预措施
1: Normal hearing children without SLI, transversal group
Normal hearing children without Specific Language Impairment (SLI),Transversal group for test-retest measures
2: Normal hearing children without SLI, longitudinal group
Normal hearing children without Specific Language Impairment (SLI), longitudinal group without training
3: Normal hearing children with SLI, longitudinal group
Normal hearing children with Specific Language Impairment (SLI), longitudinal group with training
干预措施: E-learning (Other)
4: Normal hearing adults without SLI, transversal group
Normal hearing adults without Specific Language Impairment (SLI), transversal group for test-retest measures
5: Normal hearing adults without SLI, longitudinal group
Normal hearing adults without Specific Language Impairment (SLI), longitudinal group without hearing aids (HA)
6: Hearing Impaired candidates for HA, longitudinal group
Hearing Impaired adult candidates for hearing aids (HA), longitudinal group with hearing aids (HA)
干预措施: Hearing aids fitting (Device)
结局指标
主要结局
Change from Baseline speech auditory brainstem and late responses (composite and objective measure) in response to syllables (behavioral measure)
时间窗: Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline
Spectro-temporal analysis of speech auditory brainstem and late responses : The speech brainstem and cortical responses are simultaneously obtained in response of different selected syllables from a continuum (selected by using a phonemic identification test) which is presented throughout a behavioral categorical procedure
次要结局
- Change from Baseline medial olivocochlear system (MOCS) functioning measured using the contralateral suppressive effect of transient evoked otoacoustic emissions (composite measure)(Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline)
- Change from Baseline speech-noise listening skills measured using logatomes tests (composite measure)(Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline)
- Change from Baseline dichotic skills measured using central auditory processing tests (composite measure)(Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline)