Characterization of Auditory Processing Involved in the Encoding of Speech Sounds

Not Applicable

Completed

• Conditions: Language Impairment; Hearing Loss
• Interventions: Device: Hearing aids fitting; Other: E-learning

• Registration Number: NCT02574299
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

The ability to encode the speech signal is determined by ascending and descending auditory processing. Difficulties in processing these speech signals are well described at the behavioral level in a specific language disorder. However, little is known about the underlying pathophysiological mechanisms. The assumption is that we should observe a degradation of the signal provided by the ear in the deaf subject while in case of specific language impairment it would be a phonemic disorder (possibly linked to a processing disorder auditory). The two population groups should therefore have different abnormalities of their central auditory process - which could be modified by the target remediation for each group.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-10-16
• Study First Submitted: 2015-08-14
• Study First Submitted QC: 2015-10-09
• Study First Posted: 2015-10-12
• Primary Completion: 2018-03-01
• Study Completion: 2018-03-01
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-22
• Last Update Posted: 2021-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

For all subjects:

• native French speaker
• no medical treatment for behavior or neurological disorders
• normal or corrected vision
• right-handed
• normal otorhinolaryngology examination
• valid affiliation to social security
• no participation to another research study

For the normal-hearing subjects

• normal tonal hearing thresholds
• normal tympanometry

For the subjects without specific language impairment

• aged from 6 ro 40
• normal school attendance without scholastic retardation
• normal intellectual level
• normal for age reading skills
• no delayed speech (expression & production)

For the children with specific language impairment

• aged fom 8 to 18
• persistent specific literacy difficulties with reading levels at least 18 months behind that of their peers
• normal intellectual level

For the hearing impaired subjects

• age from 18 to 70
• first auditory rehabilitation
• bilateral and symmetric hearing loss (±10 dB) with hearing thresholds between 0 and 25 dB at 0.25 kilohertz, 0 and 35 dB at 0.5 kilohertz, 0 and 50 dB at 1 kilohertz, 25 and 70 dB at 2 kilohertz, 25 and 80 dB at 3 kilohertz, 30 and 80 dB at 4 kilohertz

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Exclusion Criteria

• non signed assent
• treatment for depression, epilepsy, Parkinson's or alzheimer's disease during more than 6 months
• physical health deficiency
• mental retardation
• neurological or psychiatric disease incompatible with testing procedure

For children

• known problem of hearing loss or chronic middle ear disease whic compromized the hearing status
• schooling in a foreign language
• foreign language spoken at home with both parents

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
6: Hearing Impaired candidates for HA, longitudinal group	Hearing aids fitting	Hearing Impaired adult candidates for hearing aids (HA), longitudinal group with hearing aids (HA)
3: Normal hearing children with SLI, longitudinal group	E-learning	Normal hearing children with Specific Language Impairment (SLI), longitudinal group with training

Primary Outcome Measures

Name	Time	Method
Change from Baseline speech auditory brainstem and late responses (composite and objective measure) in response to syllables (behavioral measure)	Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline	Spectro-temporal analysis of speech auditory brainstem and late responses : The speech brainstem and cortical responses are simultaneously obtained in response of different selected syllables from a continuum (selected by using a phonemic identification test) which is presented throughout a behavioral categorical procedure

Secondary Outcome Measures

Name	Time	Method
Change from Baseline medial olivocochlear system (MOCS) functioning measured using the contralateral suppressive effect of transient evoked otoacoustic emissions (composite measure)	Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline	Measurement of the contralateral suppressive effect of transient evoked otoacoustic emissions (expressed as Equivalent Attenuation)
Change from Baseline speech-noise listening skills measured using logatomes tests (composite measure)	Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline	Presentation of disyllabic words in presence of increasing noise levels
Change from Baseline dichotic skills measured using central auditory processing tests (composite measure)	Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline	Presentation of different speech material to both ears simultaneously

Trial Locations

Locations (1)

Sercive d'Audiologie et d'Exploration Orofaciales, Hôpital Edouard Herriot, Hospices Civils de Lyon; 🇫🇷 Lyon, France