Serotonin/Dopamine Antagonism of Cocaine Effect: 2 - 2

Phase 2

Terminated

• Conditions: Cocaine-Related Disorders

• Registration Number: NCT00000310
• Lead Sponsor: National Institute on Drug Abuse (NIDA)

Brief Summary

The purpose of this study is to evaluate use of risperidone with cocaine abusers. Study measures incorporate an appropriate integration of behavioral and neurobiological indices.

Detailed Description

Risperidone in low doses is compared with placebo in a 6-week randomized trial. Subjects also receive supportive counseling. Outcome measure include rating of behavior, mood, drug abuse, global function, and urine toxicology.

Study Timeline

• Status Verified: 1996-01
• Study Start: 1996-01
• Primary Completion: 1996-03
• Study Completion: 1996-03
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Last Update Submitted: 2017-01-13
• Last Update Posted: 2017-01-16

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Cocaine abuse or dependence

Exclusion Criteria

Dependence on other drugs. Major psychiatric illness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Analog mood scales
Urine toxicology for cocaine
POMS
EPS sx

Trial Locations

Locations (1)

Brown University School of Medicine; 🇺🇸 Providence, Rhode Island, United States