ITMCTR2000003022尚未招募未知
Study for the impact of gut microbiota differences in patients with obese polycystic ovary syndrome to the curative effective differences of acupuncture between individuals
Chengdu University of Traditional Chinese Medicine0 个研究点开始时间: 待定最近更新:
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional study
入排标准
- 性别
- Female
入选标准
- •Inclusion criteria of PCOS
- •1. Infertile female with the reproductive needs, aged 20 to 40 years;
- •2. Diagnosed as having PCOS;
- •3. BMI>=25kg/m2;
- •4. Suitable for using clomiphene as ovulation induction treatment;
- •5. Sign the inform consent.
- •Inclusion criteria of health participants:
- •1. Female, aged 20 to 40 years;
- •2. BMI<25kg/m2;
- •3. Regular menstruation;
- •4. Without primary dysmenorrhea in recent 1 year;
- •5. Normal blood/stool/urine test and SAS/SDS scales;
- •6. Sign the inform consent.
排除标准
- •Exclusion criteria of PCOS:
- •1. Not diagnosed as PCOS;
- •2. Taking antibiotics history within 3 months;
- •3. Allergic constitution or allergic to various kinds of medicine;
- •4. Hyperandrogenism due to other reasons, including hyperprolactinemia, thyroid disease, congenital adrenal hyperplasia, Cushing syndrome, etc.;
- •5. Pathological endometrial changes, such as uterine malformation, hysteromyoma, etc., diagnosed by B ultrasound;
- •6. Genital tract malformation, gonadal dysgenesis, fallopian tube block, etc.;
- •7. Severe heart, liver, or renal dysfunction or hematological, respiratory, cardiovascular, psychiatric, or other metabolic disease;
- •8. Participation in other clinical trials at the same time;
- •9. Gastrointestinal surgery history;
- •10. Smoking history, alcohol history, inflammatory bowel disease, irritable bowel syndrome, autoimmune diseases, cancer and other disease that may influence the gut microbiota;
- •11. Taking probiotics with 1 month;
- •12. Suffering disease(s) causing inflammation without control;
- •13. Anxiety and depression;
- •Note: 1 to 8 are suitable for clinical observation. 1 to 13 are suitable for gut microbiota analysis.
- •Exclusion criteria of health participants:
- •1. Taking antibiotics history within 3 months;
- •2. Smoking history, alcohol history;
- •3. Diagnosed as psychosis, anxiety, depression, cognitive disorder, and allergic constitution. 4. Pregnant and breast-feeding woman;
- •5. Gastrointestinal surgery history;
- •6. Inflammatory bowel disease, irritable bowel syndrome, autoimmune diseases, cancer and other disease that may influence the gut microbiota;
- •7. Taking probiotics with 1 month;
- •8. Suffering disease(s) causing inflammation without control;
- •9. Participation in other clinical trials at the same time.
研究者
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