Repeated IPCischemic preconditioning, RIPC, ischemic reperfusion injury, endothelial function, end-stage renal disease, flow-mediated dilation (FMD)ischemisch preconditioneren (IPC), herhaalde IPC, ischemisch reperfusie schade, endotheel functie, flow-gemedieerde dilatatie
Recruiting
- Registration Number
- NL-OMON29689
- Lead Sponsor
- Radboudumc Nijmegen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Informed consent
Age > 18 years
Exclusion Criteria
-The presence of a patent arterio-venous fistula (for dialysis)
-Peripheral artery occlusive disease stage III and IV. Poor peripheral skin vascular can interfere with performance of superficial femoral artery measurements
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Brachial artery endothelial function (measured as flow-mediated dilation)
- Secondary Outcome Measures
Name Time Method To examine the effect of daily repeated ischemic preconditioning arm on superficial femoral artery function (measured as FMD%) during 7 days in patients with chronic kidney disease.<br><br /><br /><br>To examine the effect of daily repeated ischemic preconditioning on ex vivo innate immune responses