NCT02876133
Unknown
Not Applicable
Improving Colorectal Cancer Screening: Using Narrow Band Imaging for Colonic Sessile Serrated Lesions
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Colon Cancer
- Sponsor
- Hospital Beatriz Ângelo
- Enrollment
- 987
- Locations
- 3
- Primary Endpoint
- average number of serrated lesions ≥10 mm detected per colonoscopy
- Last Updated
- 7 years ago
Overview
Brief Summary
Colorectal cancer (CRC) is a leading cause of cancer death and its' incidence is rising in most European countries. Colonoscopy has been shown to reduce CRC incidence, however its effectiveness depends on the sensitivity to detect pre-malignant lesions.
Our aim is to evaluate narrow band imaging (NBI) during colonoscopy and serum miRNAs as novel tools for the early detection of colonic sessile serrated lesions (SSL). The investigators will perform a multicenter-randomized-controlled-trial to study the role of NBI in SSL detection.
Investigators
Alexandre Ferreira
Gastroenterologist
Hospital Beatriz Ângelo
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled for elective colonoscopies
Exclusion Criteria
- •known polyposis syndromes
- •primary sclerosing cholangitis
- •inflammatory bowel disease
- •personal colorectal cancer history
Outcomes
Primary Outcomes
average number of serrated lesions ≥10 mm detected per colonoscopy
Time Frame: immediate
Secondary Outcomes
- Serrated lesions <10 mm detected per colonoscopy(immediate)
- Serrated class lesions detection rate(immediate)
- Adenomas detected per colonoscopy(immediate)
- SSL detection rate(immediate)
- Adenoma detection rate(immediate)
- Advanced (malignant) adenocarcinoma detection rate(immediate)
- Incidence of procedure related adverse events(immediate)
Study Sites (3)
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