Effects of Sarcopenia on General Health Status in Elderly: a Population-based Study
- Conditions
- FrailtySarcopeniaSarcopenic Obesity
- Interventions
- Other: Sarcopenia Assessment
- Registration Number
- NCT05918159
- Lead Sponsor
- Universidade do Algarve
- Brief Summary
This is a observational study, that aimed to determine the prevalence of sarcopenia using European Wording Group on Sarcopenia in Older People (EWGSOP) algorithm in a general elderly population in Algarve region (Portugal). Because muscle is metabolically active tissue, sarcopenia may also contribute to the development of some of the metabolic disorders associated with aging. However, the risk factors associated with sarcopenia are poorly understood. Thus, a cross-sectional survey of a sample of 274 elderly adults aged 60 or over, were included in the study. Correlations of sarcopenia with functional level, lipid and glycemic profile, nutritional and physical activity level, fall risk, quality of life, and self-reported comorbidities will be studied.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 274
- Minimum age of 60 years;
- Live in the community;
- Independet Gait.
- Presence of moderate or severe cognitive impairment;
- Presence of uncontrolled cardiovascular disease and active cancer;
- Use of a pacemaker;
- Use of internal prosthesis.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Elderly Sarcopenia Assessment Group of 274 elderly
- Primary Outcome Measures
Name Time Method Prevalence of Sarcopenia in elderly population 0 Months Determine the prevalence of sarcopenia using European Wording Group on Sarcopenia in Older People (EWGSOP) algorithm in a general elderly population in Algarve region.
Quality of life in elderly population 0 Months Quality of life was assessed at one time point only (due to the nature of the cross-sectional study design) using the subscore and total score of Medical Outcomes Study 36-item Short-Form Health Survey instrument. Instrument scores can range between 0 - 100. Higher values mean better self-perception of quality of life.
- Secondary Outcome Measures
Name Time Method Fat Mass Index (kg/m2) - body composition 0 Months Fat Mass Index (kg/m2) was measured using the bioimpedance technique.
Total body water (L and %) - body composition 0 Months Total body water (L and %) was measured using the bioimpedance technique.
Reactance (Ohms) - body composition 0 Months Reactance (Ohms) was measured using the bioimpedance technique.
Resistence (Ohms) - body composition 0 Months Resistence (Ohms) was measured using the bioimpedance technique.
Cognitive Assessment 0 Months Cognitive Assessment was assessed by the instrument Montreal Cognitive Assessment (MoCA). Instrument with a maximum score of 30 points, where higher scores mean better cognitive performance.
Phase angle (angle) - body composition 0 Months Phase angle was measured using the bioimpedance technique.
Visceral fat (L) - body composition 0 Months Visceral fat (L) was measured using the bioimpedance technique.
High-density lipoprotein (HDL) cholesterol (mg/dL) - Lipid Profile 0 Months High-density lipoprotein (HDL) cholesterol (mg/dL) was measured taking a sample blood which was analysed by the COBAS b 101 system.
Total cholesterol (mg/dL) - Lipid Profile 0 Months Total cholesterol (mg/dL) was measured taking a sample blood which was analysed by the COBAS b 101 system.
Postural Stability in elderly population 0 Months Postural stability was assessed by a force platform using the length displacement of center of pressure.
Fat-Free Mass Index (kg/m2) - body composition 0 Months Fat-Free Mass Index (kg/m2) was measured using the bioimpedance technique.
Muscle Mass Index (kg/m2) - body composition 0 Months Muscle Mass Index (kg/m2) was measured using the bioimpedance technique.
Body mass index (kg/m2) - body composition 0 Months Body mass index (kg/m2) was measured using the bioimpedance technique.
Fat Mass (kg and %) - body composition 0 Months Fat Mass (kg and %) was measured using the bioimpedance technique.
Fat-Free Mass (kg and %) - body composition 0 Months Fat-Free Mass (kg and %) was measured using the bioimpedance technique.
Low-density lipoprotein (LDL) cholesterol (mg/dL) - Lipid Profile 0 Months Low-density lipoprotein (HDL) cholesterol (mg/dL) was measured taking a sample blood which was analysed by the COBAS b 101 system.
Triglycerides (mg/dL) - Lipid Profile 0 Months Triglycerides (mg/dL) was measured taking a sample blood which was analysed by the COBAS b 101 system.
Inflammatory levels in elderly population 0 Months Inflammatory levels was measured by COBAS b 101 system, taking a sample blood which was analysed for C-reactive protein - CRP.
Peak Torque (N/m) of Quadriceps and Hamstring Muscles 0 Months Peak Torque of Quadriceps and Hamstring Muscles was measured by afixed dynamometer with concentric/concentric action at an angular velocity of 60º per second for 5 repetitions of extension and flexion of each knee.
Work (N/m) of Quadriceps and Hamstring Muscles 0 Months Work of Quadriceps and Hamstring Muscles was measured by afixed dynamometer with concentric/concentric action at an angular velocity of 60º per second for 5 repetitions of extension and flexion of each knee.
Glicemic Profile in elderly 0 Months Glicemic Profile was measured by COBAS b 101 system, taking a sample blood which was analysed for Glycated Hemoglobin (HbA1c).
Nutritional level in elderly population 0 Months Nutrional level was assessed at one time point only (due to the nature of the cross-sectional study design) using a questionnaire Mini Nutritional Assessment. Instrument scores can range between 0 - 30. The cutoff points used were: 0-7 points - malnourished; 8-11 points - at risk of malnutrition; 12-24 points - normal nutritional status.
Power (N/m) of Quadriceps and Hamstring Muscles 0 Months Power of Quadriceps and Hamstring Muscles was measured by afixed dynamometer with concentric/concentric action at an angular velocity of 60º per second for 5 repetitions of extension and flexion of each knee.
Identifies the concerns and priorities of older people 0 Months Following the World Health Organisation, the "Integrated care for older people" (ICOPE) guidelines, each assessment with Age Care Technologies (ACT) Assessment generates a report which lists identifies concerns and priorities for action, together with several summary scores to measure needs, risks and outcomes, including: Quality of life, Falls risk, Vision, Hearing, Activities of Daily Living, Nutrition, Locomotor, Oral Health, Accommodation, Finances, Cognition, Depression, Loneliness, Social participation, and Violence against older people.
Peak torque time (s) of Quadriceps and Hamstring Muscles 0 Months Peak torque time of Quadriceps and Hamstring Muscles was measured by afixed dynamometer with concentric/concentric action at an angular velocity of 60º per second for 5 repetitions of extension and flexion of each knee.
Physical Activity level in elderly population 0 Months Physical activity level was assessed at one time point only (due to the nature of the cross-sectional study design) using the questionnaire PASE - Physical Activity Scale for Elderly. The PASE measures the level of self-reported physical activity in individuals aged 65 years or older and is comprised of items regarding occupational, household, and leisure activities during the previous 7-day period. It was used frequency, duration, and intensity level of activity over the previous week to assign a score, ranging from 0 to 793, with higher scores indicating greater physical activity.
Force (kg) of Quadriceps and Hamstring Muscles 0 Months Force of Quadriceps and Hamstring Muscles was measured by afixed dynamometer with concentric/concentric action at an angular velocity of 60º per second for 5 repetitions of extension and flexion of each knee.
Physical Function associated with osteoarthritis 0 Months Pain associated with osteoarthritis was mesured by Western Ontario and McMaster Universities Arthritis Index (WOMAC Index) - subscore pain. This instrument is widely used in the evaluation of Hip and Knee Osteoarthritis. It is a self-administered questionnaire consisting of 24 items divided into 3 subscales: Pain (5 items), Stiffness (2 items), and Physical Function (17 items). The test questions are scored on a scale of 0-4, which correspond to: None (0), Mild (1), Moderate (2), Severe (3), and Extreme (4). The scores for each subscale are summed up, with a possible score range of 0-20 for Pain, 0-8 for Stiffness, and 0-68 for Physical Function. Higher scores indicate worse pain, stiffness, and functional limitations.
Time up and Go (TUG) test - Fall risk in elderly population 0 Months TUG test measures (in seconds) the time a person needs to rise from a chair with armrests, to walk the distance of 3 m with usual assistive devices, if necessary, turn, return to the chair, and sit down. TUG test is a composite measure of functional mobility. It includes transfer tasks (standing up and sitting down), walking, and turning, thus incorporating neuromuscular components such as power, agility, and balance. Faster test completion signals better dexterity and functional state, whereas the score of ≥13.5 was used as a cut-off point to identify the elderly individuals who are at risk for falls in community dwelling.
Modified Falls Efficacy Scale (MFES) - Fall risk in elderly population 0 Months The Modified Falls Efficacy Scale (MFES) consists of 14 items to be subjectively evaluated on a scale of 1 to 5 in terms of confidence in the ability of a person to perform daily indoor and outdoor activities without falling. Higher values represent less risk of falling.
Pain associated with osteoarthritis 0 Months Pain associated with osteoarthritis was mesured by Western Ontario and McMaster Universities Arthritis Index (WOMAC Index) - subscore pain. This instrument is widely used in the evaluation of Hip and Knee Osteoarthritis. It is a self-administered questionnaire consisting of 24 items divided into 3 subscales: Pain (5 items), Stiffness (2 items), and Physical Function (17 items). The test questions are scored on a scale of 0-4, which correspond to: None (0), Mild (1), Moderate (2), Severe (3), and Extreme (4). The scores for each subscale are summed up, with a possible score range of 0-20 for Pain, 0-8 for Stiffness, and 0-68 for Physical Function. Higher scores indicate worse pain, stiffness, and functional limitations.
Stiffness associated with osteoarthritis 0 Months Pain associated with osteoarthritis was mesured by Western Ontario and McMaster Universities Arthritis Index (WOMAC Index) - subscore pain. This instrument is widely used in the evaluation of Hip and Knee Osteoarthritis. It is a self-administered questionnaire consisting of 24 items divided into 3 subscales: Pain (5 items), Stiffness (2 items), and Physical Function (17 items). The test questions are scored on a scale of 0-4, which correspond to: None (0), Mild (1), Moderate (2), Severe (3), and Extreme (4). The scores for each subscale are summed up, with a possible score range of 0-20 for Pain, 0-8 for Stiffness, and 0-68 for Physical Function. Higher scores indicate worse pain, stiffness, and functional limitations.
Functional Level of Lower Limbs 0 Months To assess the functionality of the lower limbs, the Lower Extremity Functional Scale (LEFS) instrument was applied. The lower extremity functional scale is a valid patient-rated outcome measure for the measurement of lower extremity function. The score can vary between 0 and 80, with higher values representing better functionality.
Handgrip strength (HGS) 0 Months HGS was measured with the handgrip Dynamometer Lafayette Digital 5030D1 in both upper limbs.
Trial Locations
- Locations (1)
Marta Botelho
🇵🇹Faro, Algarve, Portugal