Effect of 12 weeks training on muscular lipid handling in relation to type 2 diabetes mellitus.

Completed

Conditions: sugar
type 2 diabetes mellitus
10018424

Registration Number: NL-OMON30235

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

All subjects:
- Male sex
- Age 50-65 years
- BMI 27-35 kg/m2
- Stable dietary habits and physical activity levels;For diabetic patients only:
- Must be on sulphonylurea- or metformin therapy for at least six months with a
constant dose for at least two months, or on dietary treatment for at least six
months
- Well-controlled diabetes: fasting plasma glucose concentration must be <10.0
mmol/l at the time of screening.;For healthy controls only:
- normoglycemic according to WHO criteria
- no family history of diabetes

Exclusion Criteria

- Female sex
- Unstable body weight (weight gain or loss > 3 kg in the past three months)
- Participation in an intensive weight-loss program or vigorous exercise program
during the last year before the start of the study
- Active cardiovascular disease
- liver disease of liver dysfunction (ALAT>2.5 x increased)
- renal dysfunction
- systolic blood pressure >160 mmHg or diastolic blood pressure > 100 mmHg
- haemoglobin < 7.5 mmol/l (anaemia)
- use of medications know to interfere with glucose homeostasis (i.e.
corticosteroids)
- abuse of drugs and/or alcohol
- participation in another biomedical study within 1 month before the first
screening visit
- severe diabetes which requires application of insulin or patients with diabetes-
related complications

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>DAG levels, ATGL protein content, insulin sensitivity, lipid accumulation and<br /><br>mitochondrial functioning in cardiac muscle and skeletal muscle.</p><br>

Secondary Outcome Measures