Investigating the Plasticity of Human Predictive Coding Through Neuromodulation

Not Applicable

Recruiting

• Conditions: Human Brain and Cognition

• Registration Number: NCT06374433
• Lead Sponsor: Università Vita-Salute San Raffaele

Brief Summary

The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-04-08
• Study First Submitted QC: 2024-04-15
• Study First Posted: 2024-04-18
• Status Verified: 2024-06
• Study Start: 2024-06-13
• Last Update Submitted: 2024-06-13
• Last Update Posted: 2024-06-14
• Primary Completion: 2026-04-30
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 210

Inclusion Criteria

• Participant is willing and able to give informed consent for participation in the study.
• Aged 18-35 years.
• Normal or corrected to normal vision, as per anamnestic investigation.

Exclusion Criteria

• Participants with a diagnosis of epilepsy (as per anamnestic investigation).
• Participants with major neurological disorders (as per anamnestic investigation).
• Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation).
• Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Behavioral measures	During the procedure	To study if tACS or tRNS delivered in different brain networks can modulate the learning of statistical regularities in the context of visual perception we will evaluate the following behavioral measures recorded in a computerized visual perception task: hit rate, miss, false alarms, correct rejections. These behavioral measures will allow to derive measures of sensitivity (d') and response criterion (Beta and C), according to the theoretical framework of the Signal Detection Theory (SDT).

Trial Locations

Locations (1)

Università Vita-Salute San Raffaele; 🇮🇹 Milan, Italy