Investigating the Plasticity of Human Predictive Coding Through Neuromodulation: an Interventional, Monocentric, Randomized, Single-blinded Study on Healthy Adult Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 210
- 试验地点
- 1
- 主要终点
- Behavioral measures
研究概览
简要总结
The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant is willing and able to give informed consent for participation in the study.
- •Aged 18-35 years.
- •Normal or corrected to normal vision, as per anamnestic investigation.
排除标准
- •Participants with a diagnosis of epilepsy (as per anamnestic investigation).
- •Participants with major neurological disorders (as per anamnestic investigation).
- •Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation).
- •Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).
研究组 & 干预措施
Occipital tACS at IAF-2Hz
Transcranial alternating current stimulation (tACS) at occipital sites to modulate the occipital brain areas' activity at a frequency below the individual alpha frequency (IAF-2 Hz).
干预措施: Occipital tACS at IAF-2Hz (Procedure)
Occipital tACS at IAF+2Hz
Transcranial alternating current stimulation (tACS) at occipital sites to modulate the occipital brain areas' activity at a frequency above the individual alpha frequency (IAF+2 Hz).
干预措施: Occipital tACS at IAF+2Hz (Procedure)
Frontal tACS at 4-7 Hz
Transcranial alternating current stimulation (tACS) at frontal sites to modulate the frontal brain areas' activity at a frequency within the theta band (4-7 Hz).
干预措施: Frontal tACS at 4-7 Hz (Procedure)
Sham/placebo tACS
Transcranial alternating current stimulation (tACS) is applied only in the first and the last 30 seconds of the experimental procedure, thus resulting ineffective.
干预措施: Sham/placebo tACS (Procedure)
Occipital tRNS
Stimulation at occipital sites with transcranial random noise stimulation (tRNS) to modulate occipital brain areas plasticity
干预措施: Occipital tRNS (Procedure)
Frontal tRNS
Stimulation at frontal sites with transcranial random noise stimulation (tRNS) to modulate frontal brain areas plasticity
干预措施: Frontal tRNS (Procedure)
Sham/placebo tRNS
Transcranial random noise stimulation (tRNS) is applied only in the first and the last 30 seconds of the experimental procedure, thus resulting ineffective.
干预措施: Sham/placebo tRNS (Procedure)
结局指标
主要结局
Behavioral measures
时间窗: During the procedure
To study if tACS or tRNS delivered in different brain networks can modulate the learning of statistical regularities in the context of visual perception we will evaluate the following behavioral measures recorded in a computerized visual perception task: hit rate, miss, false alarms, correct rejections. These behavioral measures will allow to derive measures of sensitivity (d') and response criterion (Beta and C), according to the theoretical framework of the Signal Detection Theory (SDT).
次要结局
未报告次要终点
研究者
Luca Ronconi
Professor
Università Vita-Salute San Raffaele