Bioavailability of Potassium From Potatoes and Potassium Gluconate
- Conditions
- Potassium BioavailabilityBlood Pressure
- Interventions
- Dietary Supplement: High dose potassium gluconateDietary Supplement: Low dose potatoDietary Supplement: High dose potatoDietary Supplement: Placebo controlDietary Supplement: Low dose potassium gluconateDietary Supplement: Medium dose potatoDietary Supplement: Basal diet controlDietary Supplement: Medium dose potassium gluconateDietary Supplement: High dose French fries
- Registration Number
- NCT01881295
- Lead Sponsor
- Purdue University
- Brief Summary
This study is designed to compare the effect of sources of potassium on uptake and the effect of potassium on blood pressure.
- Detailed Description
The study will compare uptake of potassium from three different doses and sources; supplements (720, 1440 and 2160 mg) potatoes (720, 1440 and 2160 mg) or French fries (2160 mg).
During 9 phases, participants will consume a controlled diet with the supplements, potato or french fries (every other week for 5 days). On the 4th day, blood and urine samples will be taken to monitor potassium uptake and excretion. Measures of blood pressure will be analyzed at defined time points throughout the intervention.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
- Able to adhere to the visit schedule, protocol requirements and available to complete the study
- Normotensive men and women
- Aged 20-60 years
- BMI of 15-35
- Medication to treat hypertension or hypotension
- Medication known to affect electrolyte metabolism or contain high levels of potassium or sodium
- smoke cigarettes or use illegal drugs
- Hypertension or hypotension
- Diseases known to affect potassium metabolism
- Pregnant
- Allergic to nuts
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description High dose potassium gluconate High dose potassium gluconate Subjects will consume 2160 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium Low dose potato Low dose potato Subjects will consume 720 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium High dose potato High dose potato Subjects will consume 2160 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium Placebo control Placebo control Subjects will consume tablets containing no potassium in addition to a basal diet containing 2336 mg potassium Low dose potassium gluconate Low dose potassium gluconate Subjects will consume 720 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium Medium dose potato Medium dose potato Subjects will consume 1440 mg potassium in the form of potato daily in addition to a basal diet containing 2336 mg potassium Basal diet control Basal diet control Subjects will consume a basal diet containing 2336 mg potassium daily Medium dose potassium gluconate Medium dose potassium gluconate Subjects will consume 1440 mg potassium in the form of potassium gluconate tablets daily in addition to a basal diet containing 2336 mg potassium High dose French fries High dose French fries Subjects will consume 2160 mg potassium in the form of french fries daily in addition to a basal diet containing 2336 mg potassium
- Primary Outcome Measures
Name Time Method Bioavailability of Potassium 5 days After 4 days of acclimation to the supplementation, absorption of potassium will be measured.
- Secondary Outcome Measures
Name Time Method Blood Pressure Response to Potassium 6 days Differences in blood pressure will be measured between levels of potassium consumption.
Trial Locations
- Locations (1)
Purdue University
🇺🇸West Lafayette, Indiana, United States