P53 Antibody; Is it an Indicator of Dedifferentiated Thyroid Cancer?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 199
- 试验地点
- 1
- 主要终点
- There was not any risk for patients.
研究概览
简要总结
In clinical practise patients with negative radioiodine scan with positive tyhroglobulin is considered as radioiodine resistant or in another words in the process of dedifferentiation. The aim of the present study was to search a simple blood test that could lead to early identification of patients with dedifferentiation. In this respect, we investigate whether the serum level of anti-p53 antibody has the diagnostic value in the follow-up of patients with high levels of thyroglobulin (tg) and negative I-131 scan.
详细描述
In the present study enrolled were 171 patients with mean age of 47.7±13.5 yrs (range; 16-80yrs) and 28 healthy subjects with an age range of 18-52 yrs (mean: 36.0±9.8 yrs). 134 (78.4%) patients were female and 37 (21.6%) patients were male.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who were diagnosed with DTC
- •Treated with total and/or near-total thyroidectomy
- •Referred for I-131 ablation therapy or low dose I-131 whole body scan (WBS)
- •Between December 2010 and January 2013.
排除标准
- •Dose 131-I given in another hospital
- •Radioiodine treatment more than one year after thyroidectomy.
结局指标
主要结局
There was not any risk for patients.
时间窗: with in the first 8-10 months after surgery
次要结局
未报告次要终点
研究者
Zekiye HASBEK, M.D., Assistant Professor
Cumhuriyet University, School of Medicine, Department of Nuclear Medicine
Cumhuriyet University