Pediatric Caudal Epidural Dexmedetomidine Enhances Postoperative Analgesia of Magnesium Sulphate and Quality of Caudal Anesthesia in Lower Abdominal Surgeries
试验速览
- 阶段
- 2 期
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Time to first analgesic requirement
研究概览
简要总结
The study will conduct to compare the efficacy of Magnesium sulphate & dexmedetomidine used as adjuvants to bupivacaine in caudal block to provide intra-operative anesthesia as well as post -operative analgesia in pediatric patients.
详细描述
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研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 6 Months 至 6 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy male and female children, ASA I and II,Aged 6 months to 6 years, , undergoing elective surgical procedures expected to last more than 90 min, and scheduled to receive general anesthesia combined with caudal extradural block
排除标准
- •Allergy to local anesthetics,coagulation disorders, infection at site of injection, anatomic abnormalities and congenital anomalies like spina bifid, ASA III or higher, Parental refusal and the current use of Calcium Channel Blockers or Medication that may affect the neurologic system
研究组 & 干预措施
group (MG)
Magnesium sulfate 50 mg add to 1 ml/kg of 0.25%of bupivacaine
干预措施: Magnesium Sulphate (Drug)
group (D)
Dexmedetomidine 1 μg/ kg to add to 1ml/kg of 0.25%of bupivacaine
干预措施: Dexmedetomidine (Drug)
group (MD)
50 mg magnesium sulfate and Dexmedetomidine 1 μg/ kg to add to 1ml/kg of 0.25%of bupivacaine
干预措施: Dexmedetomidine + Magnesium Sulphate + Bupivacaine (Drug)
group (C)
1ml/kg of 0.25%of bupivacaine + 1 ml of normal saline
干预措施: Bupivacaine (Drug)
结局指标
主要结局
Time to first analgesic requirement
时间窗: 24 hours
The time from end of surgery to the first requirement of postoperative analgesia
次要结局
- Postoperative sedation scores(24 hours)
研究者
jehan ahmed sayed
Associate Professor (Anesthesiology and Critical Care)- College of Medicine
Assiut University