Association Between Serum Metabolism Markers and Biological Rhythm
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- circadian rhythms of serum lipid levels （the change of serum lipid levels within 24 hours）
研究概览
简要总结
The circadian regulation in mammals have been known for a long time. A special group of clock genes, organized in feedback loops, are responsible for the circadian regulation in both the SCN and peripheral organs. The central clock is mainly entrained by the light-dark cycle, while the peripheral ones in organs such as liver and intestine, are more influenced by the feeding-fasting cycles. The coordination of central and peripheral clocks is thought to be essential in the maintenance of physiological homeostasis.This study aim to investigate the association between biological rhythm and metabolism.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female；
- •Aged of 18 to 30 years old;
排除标准
- •Presence of pituitary/hypothalamic disorders, polycystic ovarian syndrome， thyroid disorders, hypertension, malignant tumor, cardiac insufficiency，hepatic or renal insufficiency, gastrointestinal disorders and acute infection;
- •Receiving psychotropic or hormonal medications including hormonal contraception and hormone therapies;
- •Taking lipid-lowering agents or hypoglycemic agents and other drugs that known to influence cardiovascular health;
- •Pregnancy or lactation women;
- •Obviously poor compliance.
结局指标
主要结局
circadian rhythms of serum lipid levels （the change of serum lipid levels within 24 hours）
时间窗: Measured at baseline, and every 10 years during the 40-year follow-up period
次要结局
- change in urine metabolite(Measured at baseline, and every 10 years during the 40-year follow-up period)
- change in sperm quality(Measured at baseline, and every 10 years during the 40-year follow-up period)
- circadian rhythms of gonadal hormone and gonadotropin（the change of gonadal hormone and gonadotropin within 24 hours）(Measured at baseline, and every 10 years during the 40-year follow-up period)
- circadian rhythms of serum total bile acids（the change of serum total bile acids within 24 hours）(Measured at baseline, and every 10 years during the 40-year follow-up period)
- change in intestinal flora(Measured at baseline, and every 10 years during the 40-year follow-up period)
研究者
Jia-jun Zhao
Professor
Shandong Provincial Hospital