Effect of Lidocaine Sprayed on Hemodynamics During Endotracheal Intubation

Not Applicable

• Conditions: Neurosurgical Patients
• Interventions: Drug: group L; Drug: group C; Drug: group V; Drug: group LV

• Registration Number: NCT01737437
• Lead Sponsor: Seoul National University Hospital

Brief Summary

A previous study demonstrated topical lidocaine spray on the larynx and the trachea is effective in reducing hemodynamic response to laryngoscopy and endotracheal intubation. In clinical practice, blind oropharyngeal application of lidocaine without aiding direct laryngoscopy can not assured that sprayed lidocaine effectively reaches the larynx and trachea. Therefore, direct laryngoscopy should be necessary to reach topical lidocaine to correct sites. Unfortunately, direct laryngoscopy itself can affect hemodynamics during spraying lidocaine. In this study, we will investigate an effect of lidocaine sprayed on direct laryngoscopy and the tracheal mucosa on hemodynamic change throughout intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10
• Status Verified: 2012-11
• Study First Submitted: 2012-11-20
• Study First Submitted QC: 2012-11-26
• Last Update Submitted: 2012-11-26
• Study First Posted: 2012-11-29
• Last Update Posted: 2012-11-29
• Primary Completion: 2013-01
• Study Completion: 2013-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• aged 20-60 years,
• ASA groups I or II

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Exclusion Criteria

• ASA III or IV,
• hypertension,
• anticipated difficult airway, and
• severe coronary and cerebrovascular diseases

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group L	group L	10% Lidocaine was applied to the laryngoscope blade and 0.9% normal saline was applied to the trachea.
group C	group C	0.9% normal saline was applied to trachea and laryngoscope blade in Group C.
group V	group V	0.9% normal saline was applied to the laryngoscope blade and 10% Lidocaine was applied on trachea.
group LV	group LV	10% Lidocaine was applied on laryngoscope blade and trachea.

Primary Outcome Measures

Name	Time	Method
mean blood pressure, heart rate	baseline, at laryngoscope insertion, 60s after laryngoscope insertion, during intubation, one, two, three min after endotracheal intubation

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of