Effect of Lidocaine Sprayed on Direct Laryngoscopy and Trachea on Hemodynamics During Endotracheal Intubation
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- mean blood pressure, heart rate
研究概览
简要总结
A previous study demonstrated topical lidocaine spray on the larynx and the trachea is effective in reducing hemodynamic response to laryngoscopy and endotracheal intubation. In clinical practice, blind oropharyngeal application of lidocaine without aiding direct laryngoscopy can not assured that sprayed lidocaine effectively reaches the larynx and trachea. Therefore, direct laryngoscopy should be necessary to reach topical lidocaine to correct sites. Unfortunately, direct laryngoscopy itself can affect hemodynamics during spraying lidocaine. In this study, we will investigate an effect of lidocaine sprayed on direct laryngoscopy and the tracheal mucosa on hemodynamic change throughout intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 20-60 years,
- •ASA groups I or II
排除标准
- •ASA III or IV,
- •hypertension,
- •anticipated difficult airway, and
- •severe coronary and cerebrovascular diseases
研究组 & 干预措施
group L
10% Lidocaine was applied to the laryngoscope blade and 0.9% normal saline was applied to the trachea.
干预措施: group L (Drug)
group C
0.9% normal saline was applied to trachea and laryngoscope blade in Group C.
干预措施: group C (Drug)
group V
0.9% normal saline was applied to the laryngoscope blade and 10% Lidocaine was applied on trachea.
干预措施: group V (Drug)
group LV
10% Lidocaine was applied on laryngoscope blade and trachea.
干预措施: group LV (Drug)
结局指标
主要结局
mean blood pressure, heart rate
时间窗: baseline, at laryngoscope insertion, 60s after laryngoscope insertion, during intubation, one, two, three min after endotracheal intubation
次要结局
未报告次要终点
研究者
Hee-Pyoung Park
Professor
Seoul National University Hospital