Probiotics Against Pathogenic Bacteria in Connection With Anaesthesia
- Conditions
- Oropharyngeal Microbiology
- Registration Number
- NCT01521650
- Lead Sponsor
- Region Skane
- Brief Summary
Longer surgical procedures require intubation and there is a potential risk of contaminating the lower airways with pathogenic bacteria from the mouth and oropharynx.
Healthy people seldom have pathogenic bacteria originating from the gastro-intestinal canal but those do occur among patients, both in those not so sick and patients with more severe problems.
For ICU patients we have seen a reduction of emerging enteric bacteria in patients given oral care with probiotics and this is a pilot study to explore the possibility of the same kind of positive effects in patients due for longer (more than 4 hours of anesthesia) procedures.
Randomisation
* No prophylaxis
* Preparation with a probiotic suspension before intubation.
Cultures
* oropharynx
* before treatment
* after intubation
* before extubation
* day 1 postoperatively
* tracheal secretions
* after intubation
* before extubation
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 42
- Adult patients
- Planned interventions
- Anaesthesia > 4 hours and requiring intubation
- Ulcers in the mouth, oropharynx, oesophagus and stomach
- Current infections in the airways
- Known immuno deficiences
- Emergency cases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Differences in pathogenic bacteria in the oropharynx and lower airways During hospitalization, up to 4 weeks Emerging and resident bacteria will be compared for the cultures taken in the oropharynx and from tracheal secretions in conection with anaestesia and a surgical intervention
- Secondary Outcome Measures
Name Time Method Pneumonia Up till 7 days postoperatively X-ray verified infiltrations in combination with expectorates
Length of hospital stay time to discharged from hospital or patients death Comparison of length of stay between the intervention group and the control group
White blood cells During hospitalization, up to 4 weeks WBC taken pre-op and days 1,2,3 post-op
CRP During hospitalization, up to 4 weeks CRP taken pre-op and days 1,2,3 post-op
Trial Locations
- Locations (1)
Lund University Hospital
🇸🇪Lund, Sweden
Lund University Hospital🇸🇪Lund, Sweden