The impact of trans-jugular intrahepatic portosystemic shunts on muscle mass in chronic liver disease.

Not Applicable

Completed

• Conditions: cirrhosis; portal hypertension; sarcopenia; Trans-jugular intrahepatic portosystemic shunt; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12619000081112
• Lead Sponsor: Department of Gastroenterology and Hepatology, Austin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-01-21
• Study Completion: 2022-04-18
• Last Update Posted: 23 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

Adult patients > 18 years old with a diagnosis of cirrhosis on biochemical, clinical, histological or radiological criteria
Referred for TIPS for treatment of complications of portal hypertension
Patients who have had a CT abdomen (including the L3 vertebrae) performed 6 weeks prior or within 48 hours of TIPS procedure

Exclusion Criteria

TIPS for in patients without confirmed cirrhosis
Patients unable to perform physical assessments (including handgrip strength) at the time of TIPS procedure due to reduced conscious state or intubation in intensive care.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Skeletal muscle index as measured on a single slice CT at the 3rd lumbar vertebrae[CT scan prior to TIPS will be compared to a single slice scan taken at 6 months post TIPS]