Evaluation of Maternal Serum Stathmin-1 Levels as a Biomarker in Preeclampsia and Severe Preeclampsia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Maternal Serum Stathmin-1 Levels
研究概览
简要总结
The goal of this observational study is to investigate maternal serum Stathmin-1 levels in pregnancies affected by preeclampsia compared to healthy gestations.
The main questions it aims to answer are:
- What are the maternal serum Stathmin-1 levels in pregnancies with preeclampsia?
- How do Stathmin-1 levels differ between preeclampsia with severe features and uncomplicated pregnancies?
Researchers will compare Stathmin-1 levels in pregnancies with preeclampsia and preeclampsia with severe features to those in a control group of healthy pregnancies to assess differences in biomarker levels.
Participants will undergo blood sample collection at 32-34 weeks of gestation. Have their blood samples processed for Stathmin-1 level measurement using ELISA.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Gestational Age: Pregnancies between 20 weeks and term (up to 40 weeks).
- •Diagnosis of Preeclampsia (PE): New-onset hypertension (systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg) after 20 weeks of gestation, with or without proteinuria.
- •Diagnosis of Severe Preeclampsia: Defined by criteria such as severe hypertension (systolic BP ≥160 mmHg or diastolic BP ≥110 mmHg), organ dysfunction (renal insufficiency, liver involvement, neurological complications), thrombocytopenia, pulmonary edema, or fetal growth restriction.
- •Control Group: Healthy pregnancies without preeclampsia or other significant maternal or fetal complications.
排除标准
- •Multiple Pregnancies: Participants carrying more than one fetus.
- •Pregestational Diabetes: Pre-existing diabetes mellitus diagnosed before pregnancy.
- •Chronic Hypertension: Pre-existing hypertension diagnosed before pregnancy or before 20 weeks of gestation.
- •Systemic Diseases: Chronic kidney disease, autoimmune diseases, or other significant systemic illnesses.
- •Fetal Anomalies: Identified structural or genetic abnormalities in the fetus.
- •Premature Rupture of Membranes: Spontaneous rupture of membranes before the onset of labor at term (37 weeks of gestation) or preterm (before 37 weeks of gestation).
结局指标
主要结局
Maternal Serum Stathmin-1 Levels
时间窗: Measured at the time of diagnosis and followed up until delivery.
To identify and compare Maternal Serum Stathmin-1 Levels levels between the pre-eclampsia group, severe pre-eclampsia group, and the control group. This will help in understanding the biochemical environment associated with pre-eclampsia and its severity.
次要结局
未报告次要终点
研究者
Burak Yücel
Assoc. Professor
Burak Yücel Special Clinic