Retrospective analysis of blood biomarkers in cardiac surgery patients with postoperative neurocognitive disorders and sub-clinical brain infarcts
- Conditions
- Postoperative cognitive decline
- Registration Number
- DRKS00031711
- Lead Sponsor
- Kerckhoff-Klinik, Heart and Brain Research Group
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
1.Elective cardiac surgery (on pump)
a.Aortic valve replacement (AVR)
b.Mitral valve replacement/reconstruction (MVR)
c.Combination (Coronary artery bypass grafting (CABG)+AVR, CABG+MVR, AVR+MVR, CABG+AVR+MVR)
2.Sufficient knowledge of the German language, as the neuropsychological tests are language-dependent
3.Written informed consent of the patients to participate in the studies
4.Available biomaterial
Exclusion Criteria
- previous cardiac surgery
- preoperative psychiatric illness (dementia, depression) with acute symptoms that could interfere with neuropsychological testing
- preoperative neurological diseases (stroke) with acute symptoms that could interfere with neuropsychological testing
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Which blood biomarkers are associated with the development of postoperative cognitive decline (POCD) in both patients with and without postoperative subclinical brain infarcts?
- Secondary Outcome Measures
Name Time Method