Evaluation of Glomerular Filtration Rate Using Iohexol Plasma Clearance in Critically Ill Patients With Augmented Renal Creatinine Clearance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- GFR obtained by the iohexol clearance technique
研究概览
简要总结
Evaluation of glomerular filtration rate using iohexol plasma clearance in critically ill patients with augmented renal creatinine clearance
详细描述
Single center study in ICU patients with augmented renal clearance comparing glomerular filtration rate (GFR) as measured by iohexol plasma clearance to that measured by creatinine clearance. Primary objective is to compare the GFR estimates made by iohexol plasma clearance (as reference method) and creatinine clearance using Bland-Altman method.
Secondary objective are to compare GFR as measured by iohexol plasma clearance to that calculated with the most commonly used renal clearance estimating formulas (Cockcroft and Gault, MDRD and CKD-EPI ), evaluate clinical determinant of the observed differences and evaluate determinants of extracellular volume.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICU patient
- •24h Creatinine clearance >130ml/min/1.73m2
- •Urinary catheterization
- •Affiliation to a social security scheme
排除标准
- •Pregnancy
- •CT-scan with contrast media infusion the day of inclusion
- •Documented allergy to contrast media
- •Patient under guardianship / curatorship
- •Patient benefiting from the "State Medical Assistance"
研究组 & 干预措施
Critically ill patients with augmented renal clearance
ICU patients with estimated renal clearance over 130ml/min/1.73m2
干预措施: Iohexol (Drug)
结局指标
主要结局
GFR obtained by the iohexol clearance technique
时间窗: 6 hours
GFR as measured by iohexol plasma clearance to evaluate its concordance, by the Bland and Altman method, with that obtained by measuring the clearance of creatinine.
GFR obtained by the creatinine clearance technique
时间窗: 6 hours
GFR as measured by creatinine plasma clearance
次要结局
- Plasmatic Levetiracetam dosing(6 hours)
- Plasmatic Cefotaxim dosing(6 hours)
- GFR calculated using the Cockroft-Gault equation(6 hours)
- GFR calculated using the Modification of diet in renal disease (MDRD) formula(6 hours)
- GFR calculated using the Chronic Kidney Disease - Epidemiology Collaboration (CKD-EPI) equation(6 hours)
- Plasmatic Vancomycin dosing(6 hours)
- Plasmatic Piperacillin dosing(6 hours)
- Plasmatic Aminoglycoside dosing(6 hours)