The effect of vitamin C on acute MI in primary PCI setting
- Conditions
- acute myocardial infarction.Acute transmural myocardial infarction of unspecified site
- Registration Number
- IRCT201606048698N19
- Lead Sponsor
- Vice chancellor for research, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 320
inclusion criteria:
Subjects (men or women) at least 18 years and less than 80 years of age; Ischemic discomfort =20 minutes and =6 hours of duration;
ST elevation =1mm (=0.1mV) in two contiguous limb leads OR =2mm (=0.2mV) in two contiguous precordial leads; Planned primary PCI within 2 hours of hospital presentation; Planned or concomitant use of aspirin, clopidogrel, unfractionated heparin, and Glycoprotein IIb/IIIa inhibition with intent to stent the infarct-related artery; Informed consent able to be obtaine
Age =80 years; Cardiac arrest or arrhythmia requiring chest compressions or cardiopulmonary resuscitation; Current warfarin therapy; Known allergy or contraindication to fibrinolytics OR aspirin OR heparin OR clopidogrel; Patients with evidence of coronary collaterals (2-3 Rentrop) to the region at risk on previous coronary angiography (at the previous admission) .
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Myocardial infarction. Timepoint: before intervention. Method of measurement: clinical history and ECG.;Myocardial perfusion grade. Timepoint: after PCI. Method of measurement: by angiographic interpretation.;TIMI flow. Timepoint: after stenting. Method of measurement: by angiographic interpretation.;P selectin kit. Timepoint: one month. Method of measurement: ELISA.
- Secondary Outcome Measures
Name Time Method