Cumulative Pregnancy Rates and Direct Healthcare Cost Analysis of Two Different Strategies: Fresh Cleavage-stage Embryo Transfer (ET) on Day 3 With Vitrification of Supernumerary Embryos on Day 3 Versus Day 5
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Subfertility
- Sponsor
- Sophie Debrock
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- cumulative pregnancy rate
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This monocenter academic study aims to evaluate the effectiveness and cost effectiveness of two different strategies: fresh Embryo Transfer (ET) on day 3 followed by cryopreservation of cleavage-stage (Day 3) embryos versus blastocyst-stage (Day 5) embryos.
The primary outcome is the cumulative pregnancy rate after all transfers (fresh and/or frozen embryo transfer cycles which might take about 1 year), up to two sequential cycles. The secondary outcome concerns a cost analysis of both strategies from the healthcare payer's perspective.
Investigators
Sophie Debrock
Professor, PhD
KU Leuven
Eligibility Criteria
Inclusion Criteria
- •subfertile women planned for the first or second oocyte retrieval for in vitro fertilisation (IVF)/Intracytoplasmic sperm injection (ICSI) treatment
- •who are older than 18 and less than 38 years old
- •who have normal Follicle Stimulating Hormone (FSH) and normal Anti-Mullerian Hormone (AMH) levels
Exclusion Criteria
- •treatment with donor oocytes or donor embryos
- •patients planned for Pre-implantation Genetic Diagnosis (PGD)
- •Patients with BMI\>30
- •patients with endometriosis grade III-IV
Outcomes
Primary Outcomes
cumulative pregnancy rate
Time Frame: Cumulative pregnancy is measured after two consecutive IVF cycles including fresh and frozen transfers which might take about 1 year
The cumulative pregnancy rate after all transfers (fresh and/or frozen embryo transfer cycles)
Secondary Outcomes
- cost analysis(Cumulative pregnancy is measured after two consecutive IVF cycles including fresh and frozen transfers which might take about 1 year)