CTRI/2023/01/049006
Not yet recruiting
Phase 4
Anticoagulation for Stroke Prevention In patients with Recent Episodes of perioperative Atrial Fibrillation after noncardiac surgery - ASPIRE-AF
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Health Condition 1: I48- Atrial fibrillation and flutterHealth Condition 2: I63- Cerebral infarction
- Sponsor
- Population Health Research Institute
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.noncardiac surgery with at least an overnight hospital admission after surgery in the last 35 days;
- •2\.\=1 episode of clinically important perioperative AF during or after their surgery;
- •3\.sinus rhythm at the time of randomization; AND
- •4\.any of the following high\-risk criteria:
- •a.age 55\-74 years, and having either known cardiovascular disease, recent major vascular surgery, or a CHA2DS2VASc score \=3;OR
- •b.age \=75 years.
Exclusion Criteria
- •1\.history of documented AF prior to noncardiac surgery;
- •2\.need for long\-term systemic anticoagulation;
- •3\.ongoing need for long\-term dual antiplatelet treatment;
- •4\.contraindication to oral anticoagulation;
- •5\.severe renal insufficiency (eGFR \<30 ml/min);
- •6\.acute stroke in the past 3 months;
- •7\.underwent cardiac surgery in the past 3 months;
- •8\.history of nontraumatic intracranial, intraocular, or spinal bleeding;
- •9\.hemorrhagic disorder or bleeding diathesis;
- •10\.expected to be non\-compliant with follow\-up and/or study medications;
Outcomes
Primary Outcomes
Not specified
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