CTRI/2023/01/049006尚未招募4 期
Anticoagulation for Stroke Prevention In patients with Recent Episodes of perioperative Atrial Fibrillation after noncardiac surgery - ASPIRE-AF
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1.noncardiac surgery with at least an overnight hospital admission after surgery in the last 35 days;
- •2.=1 episode of clinically important perioperative AF during or after their surgery;
- •3.sinus rhythm at the time of randomization; AND
- •4.any of the following high-risk criteria:
- •a.age 55-74 years, and having either known cardiovascular disease, recent major vascular surgery, or a CHA2DS2VASc score =3;OR
- •b.age =75 years.
排除标准
- •1.history of documented AF prior to noncardiac surgery;
- •2.need for long-term systemic anticoagulation;
- •3.ongoing need for long-term dual antiplatelet treatment;
- •4.contraindication to oral anticoagulation;
- •5.severe renal insufficiency (eGFR <30 ml/min);
- •6.acute stroke in the past 3 months;
- •7.underwent cardiac surgery in the past 3 months;
- •8.history of nontraumatic intracranial, intraocular, or spinal bleeding;
- •9.hemorrhagic disorder or bleeding diathesis;
- •10.expected to be non-compliant with follow-up and/or study medications;
- •11.known life expectancy less than 1 year due to concomitant disease;
- •12.women who are pregnant, breastfeeding, or of childbearing potential who are not taking effective contraception; OR
- •13.previously enrolled in the trial
研究者
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