Fluid restriction versus no active treatment in chronic SIAD

Not Applicable

Completed

• Conditions: Chronic asymptomatic syndrome of inappropriate antidiuresis (SIAD); Nutritional, Metabolic, Endocrine; Syndrome of inappropriate antidiuresis (SIAD)

• Registration Number: ISRCTN34822127
• Lead Sponsor: Beaumont Hospital

Brief Summary

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32879954/ results (added 05/08/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-04-27
• Study Completion: 2020-01-31
• Last Update Posted: 17 August 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

1. Age > 18 years
2. Chronic hyponatraemia with plasma sodium 120 - 130 mmol/L
3. Euvolemia and biochemical confirmation of SIAD.

Exclusion Criteria

1. Symptomatic hyponatraemia
2. Plasma sodium < 120 mmol/L
3. An underlying cause for hyponatraemia is recognised which is temporary or rapidly reversible with treatment of the underlying condition or removal of the causative medication
4. Hypo- or hyper-volemia
5. Diuretic therapy
6. Uncontrolled hyperglycaemia (blood glucose > 16.6 mmol/L)
7. Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified