ISRCTN34822127
Completed
未知
A prospective randomised controlled trial comparing the effects of fluid restriction with no active hyponatremia treatment on rate of change of plasma sodium, and markers of hyponatraemia related morbidity, in patients with chronic hyponatremia due to the syndrome of inappropriate antidiuresis.
Beaumont Hospital0 sites46 target enrollmentApril 27, 2018
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Chronic asymptomatic syndrome of inappropriate antidiuresis (SIAD)
- Sponsor
- Beaumont Hospital
- Enrollment
- 46
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32879954/ results (added 05/08/2021)
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Age \> 18 years
- •2\. Chronic hyponatraemia with plasma sodium 120 \- 130 mmol/L
- •3\. Euvolemia and biochemical confirmation of SIAD.
Exclusion Criteria
- •1\. Symptomatic hyponatraemia
- •2\. Plasma sodium \< 120 mmol/L
- •3\. An underlying cause for hyponatraemia is recognised which is temporary or rapidly reversible with treatment of the underlying condition or removal of the causative medication
- •4\. Hypo\- or hyper\-volemia
- •5\. Diuretic therapy
- •6\. Uncontrolled hyperglycaemia (blood glucose \> 16\.6 mmol/L)
- •7\. Pregnancy
Outcomes
Primary Outcomes
Not specified
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