CTRI/2021/04/032858招募中4 期
Digoxin in patients with rheumatic heart disease - a randomised placebo-controlled trial
试验速览
- 阶段
- 4 期
- 状态
- 招募中
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Age >= 18 years
- •2. RHD documented by echocardiography
- •3. Already on treatment with digoxin as advised
- •by their treating doctors
- •4. Not already on digoxin, but haveeither of
- •the following conditions:
- •i. Heart failure - diagnosed in the presence
- •of current or past clinical symptoms
- •(limitation of activity, fatigue, and
- •dyspnea, orthopnea or paroxysmal nocturnal
- •dyspnea), signs (edema, elevated jugular
- •venous pressure, or rales), or radiologic
- •evidence of pulmonary congestion
- •ii. Atrial fibrillation or flutter -documented
- •on a 12-lead ECG
排除标准
- •1. Significant renal insufficiency (serum
- •creatinine >2 mg/dL)
- •2. Uncorrected hypokalemia ( <3.2 mmol/L) or
- •hyperkalemia ( >5.5 mmol/L)
- •3. Presence of sinus bradycardia (HR <50/min),
- •II or III degree AV block, sick sinus
- •syndrome or pre-excitation
- •4. Physician does not wish to start digoxin
- •5. Coexisting coronary artery disease or other
- •cardiac conditions (hypertrophic, dilated or
- •restrictive cardiomyopathies)
- •6. Patients with mechanical heart valves
- •(however, patients who undergo mechanical
- •valve replacement surgery during the course
- •of the study will be continued on study
- •7. Pregnant women
- •8. Presence of severe comorbid conditions which
- •may limit life expectancy to <2 years
研究者
相似试验
进行中（未招募）
1 期
Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the NetherlandsHeart failureEUCTR2018-003789-15-NLDepartment of Cardiology, Hartcentrum, University Medical Center Groningen982
招募中
4 期
Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the NetherlandsHeart failure10019280NL-OMON55484niversitair Medisch Centrum Groningen982
已完成
4 期
A Prospective Study of Different Digoxin Treatment Regimens in Egyptian HospitalAtrial FibrillationNCT02489786Cairo University71
已完成
不适用
Benefit of Digoxin in Right Heart Failure Due to Chronic lung DiseasesCTRI/2020/07/026293veer surendra sai institute of medical science120
已完成
4 期
Efficacy Study of Digoxin & Ivabradine to Treat Heart FailureCardiac FailureNCT01699776Cocco, Giuseppe, M.D.22