Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study

• Conditions: Parkinson's Disease

• Registration Number: NCT00282802
• Lead Sponsor: The Parkinson's Institute

Brief Summary

The purpose of this study is to examine the role of genetic and environmental factors in the cause of Parkinson's disease.

Detailed Description

Parkinson's disease (PD) is a growing health problem in the elderly, and genetic factors may provide substantial clues toward eventual treatment and/or prevention of the disorder. The National Academy of Sciences/National Resource Council (NAS/NRC) World War II (WWII) Veteran Twins Cohort Registry is one of the few population-based groups of elderly twins. Previous studies in this group indicated that genetic factors were involved only in early-onset PD, however there was no follow-up to these studies.

The purpose of the "Twins and the Risk of PD" study is to follow-up previous studies and confirm the initial findings. In this study, investigators will use the NAS/NRC WWII Veteran Twin Cohort Registry to compare the concordance rates for PD in monozygotic and dizygotic twins-at least one of whom has PD.

The overall goal of this research is determine the contributions of genetic and environmental factors in the cause of PD.

The study will involve traditional clinical research methods, such as a clinical examination, as well as innovative imaging techniques, such as single photon emission computed tomography (SPECT). SPECT-a nuclear imaging test involving blood flow to tissue-is used to evaluate certain brain functions.

Findings from this study may help to set research priorities in PD, and to develop tools for early detection of the disorder.

Study Timeline

• Study Start: 2001-04
• Study First Submitted: 2006-01-26
• Study First Submitted QC: 2006-01-26
• Study First Posted: 2006-01-27
• Status Verified: 2009-07
• Last Update Submitted: 2009-07-01
• Last Update Posted: 2009-07-02
• Study Completion: 2010-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 250

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Onset of Parkinson's disease	duration of the project

Secondary Outcome Measures

Name	Time	Method
Age of Parkinson's disease onset	duration of the project

Trial Locations

Locations (1)

The Parkinson's Institute, 675 Almanor Avene; 🇺🇸 Sunnyvale, California, United States