The effects of exercise training combined with NR supplementation on metabolic health in older individuals

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 72

Inclusion Criteria

• Participants are able to provide signed and dated written informed consent
prior to any study specific procedures
• Aged >= 65 and <= 80 years
• Body mass index (BMI) 25 - 35 kg/m2
• Stable dietary habits (no weight loss or gain > 5 kg in the past 3 months)
• No signs of active cardiovascular disease, liver or kidney malfunction

Exclusion Criteria

• Type 2 diabetes
• Patients with congestive heart failure and and/or severe renal and or liver
insufficiency
• Uncontrolled hypertension
• Any contra-indication for MRI scanning
• Alcohol consumption of >3 servings per day for man and >2 servings per day
for woman
• Smoking
• Unstable body weight (weight gain or loss > 5kg in the last 3 months)
• Engagement in structured exercise activities > 2 hours a week
• Previous enrolment in a clinical study with an investigational product during
the last 3 months or as judged by the Investigator which would possibly hamper
our study results
• Medication use known to hamper subject*s safety during the study procedures
• Subjects who do not want to be informed about unexpected medical findings
• Subjects who intend to donate blood during the intervention or subjects who
have donated blood less than three months before the start of the study
• Use of food supplements containing NR or Resveratrol (similar working
mechanisms)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study endpoints is ex vivo skeletal muscle mitochondrial function<br /><br>measured via high-resolution respirometry. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study outcome is sleeping metabolic rate measured during an<br /><br>overnight stay in the respiration chamber.<br /><br>Explorative objectives are muscle (NAD) metabolites, energy metabolism and<br /><br>physical performance.</p><br>