Relationship of Blood Pressure Variability and Cardiovascular Disease Events Among Patients With Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,736
- 试验地点
- 1
- 主要终点
- The standard deviation value of blood pressure variability in treated hypertensive patients
研究概览
简要总结
Cardiovascular Disease (CV) including stroke is the leading cause of death in Malaysia Hypertension is a major contributor to this. Prevalence of hypertension in Malaysia is high (42%) in adults age 30 years or older. Besides the actual blood pressure (BP) level recently, blood pressure variability (BPV) has been recognized as an independent and strong predictor of CV events especially strokes. However, data on the BP variability and its relationship to CV events is very limited in Asia, particularly in Malaysia. Hence the investigators aim to study BPV and its relationship to CV events in treated hypertensive patients
详细描述
This will be a cross-sectional study on patients with hypertension. The 10-year retrospective data on BP, treatment, biochemical changes, kidney function and CV events will be extracted from patient records.
Eligible patients who have given written informed consent will be given a questionnaire capturing data of their socio-demographic status, weight, height and BP measured.
Those agreeable to measure their own BP at home 3 times a day for a week will be loaned a BP device to measure their own BP at home. The home BP readings will be recorded onto a provided form and returned to the investigators.
Data will be analysed to
- determine BPV of the clinic visit-to-visit BPV (long tem BPV)
- determine the day to day BPV (short term BPV)
- examine the BPV to CV events, kidney function, cognition
- determine the prevalence of white coat and masked hypertension
- determine the level of control of BP
- examine the relationship of ownership of home BP devices to control and satisfaction of treatment
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients on treatment for hypertension of at least 3 years
- •Patients who consent to the study
排除标准
- •those unable to give consent
- •recent (less than 6 months) of cardiovascular events (stroke, heart attack, heart failure)
- •patients on dialysis
- •patients with end stage kidney failure
结局指标
主要结局
The standard deviation value of blood pressure variability in treated hypertensive patients
时间窗: 31 Dec 2020
The various indices of day-to-day and long term Blood pressure variability will be calculated giving the actual BPV (in absolute number ) in these patients
Percentage of cardiovascular events in those with higher BPV compared to those with lower BPV
时间窗: 31 Dec 2020
BPV will be categorized as above or below the mean BPV of the entire group. The number of CV events in percentage in each group will be compared It is expected that those with higher BPV will have more CV events
次要结局
- Percentage of Treated hypertensives with White Coat or Masked hypertension(31 Dec 2020)
- Difference in cognition in those with higher BP variability compared to those with lower BPV(31 Dec 2020)
研究者
Professor Chia Yook Chin
Professor
University of Malaya