NCT00585156终止早期 1 期
The Effects of Celecoxib on Bone Ingrowth in Porous Coated Titanium Ceramic Implants in Humans
适应症
干预措施
试验速览
- 阶段
- 早期 1 期
- 状态
- 终止
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Bone Ingrowth
研究概览
简要总结
The purpose of this study is to evaluate the effect of Celebrex on bone growth into porous coated implants, following postoperative total knee arthroplasty administration of Celebrex for pain relief.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male VA bilateral TKA patients 18 years or older with primary OA diagnosis
排除标准
- •Patients with osteoporosis, hypersensitivity to Celebrex, allergy to tetracycline, Sulfonamides, patient with asthma, urticaria, or allergic-type reactions to aspirin or NSAIDs.
- •Patients who have had CABG.
- •Patients with a history of peptic ulcer disease, duodenal ulcers.
- •Female patients and patients diagnosed with unstable hypertension or hypotensive, with serum creative levels above 1.8-2.0 or diagnosed with severe renal disease.
研究组 & 干预措施
Arm #1
Experimental
Celebrex treatment group
干预措施: Celecoxib (Drug)
结局指标
主要结局
Bone Ingrowth
时间窗: 12 weeks
次要结局
- Pain Score(10 days postoperative)
研究者
研究点 (1)
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