NL-OMON56940尚未招募不适用
Quantitative MRI for Blood Brain Barrier integrity Assessment without Gadolinium Based Contrast Agents - MRI BBB Integrity assessment GBCA-Free
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 230
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age => 18 year
- •Patients from these pathologies will be included:
- •* Brain Tumors.
- •Rationale: Contrast MRI is instrumental in detecting brain tumors, as these
- •agents help to delineate tumor margins, show the vascular supply, and highlight
- •areas of neovascularity or breakdown of the normal blood-brain barrier.
- •* Infections.
- •Rationale: In cases of brain infections like abscesses, encephalitis, or
- •meningitis, contrast MRI can help in defining the extent of the infection and
- •differentiating it from other pathologies.
- •* Multiple Sclerosis (MS).
- •Rationale: For MS, contrast MRI can help in identifying active versus inactive
- •lesions. Active lesions will typically take up the contrast agent due to the
- •breakdown of the blood-brain barrier.
- •* Inflammatory Conditions.
- •Rationale: Diseases like sarcoidosis or autoimmune disorders such as vasculitis
- •may also be evaluated with contrast MRI to understand the extent of
- •inflammation and its effects on brain tissue.
- •* Demyelinating Diseases.
- •Rationale: Besides MS, other demyelinating conditions might also show contrast
- •enhancement where there is active inflammation.
- •* Metastasis.
- •Rationale: Contrast MRI helps in the detection of metastatic cancer to the
- •brain, often revealing multiple lesions with a characteristic appearance.
- •* Post-Treatment Evaluation.
- •Rationale: Following surgery, radiation, or chemotherapy, contrast MRI can help
- •in monitoring for recurrence or progression of disease.
排除标准
- •Patients with other pathologies even those which contrast agent is usually
- •prescribed such as vascular malformations, aneurysms, congenital malformations
- •and other vascular anomalies are excluded.
- •A patient who meets any of the following criteria will be excluded from
- •participation in this study:
- •* Subjects with a typical contra-indication to an MRI exam.
- •* Subjects with metal implants.
- •* Subjects who have a documented allergy to MRI contrast media or a
- •contra-indication for contrast-media or will not undergo contrast-enhanced MRI.
- •* Woman who are pregnant or lactating
- •* Having any physical or mental status that interferes with the informed
- •consent procedure
研究者
相似试验
招募中
Unknown
Blood-brain barrier function assessed with MRI in cognitive deficits in neurological disordersAlzheimer disease, Dementia with Lewy bodies, Parkinson disease, Parkinsonism related disordersJPRN-UMIN000049624Kyoto University Hospital250
撤回
不适用
Evaluation of Blood Brain Barrier Integrity and Relationship to Structural Brain Abnormalities in MPS IIIB Patients Using Cerebrospinal Fluid/Serum Albumin Index (CSF-AI) and Multimodal Magnetic Resonance ImagingSanfilippo BSanfilippo disease10021605NL-OMON38912Synegeva6
招募中
不适用
Measuring blood-brain barrier integrity non-invasively with MRIdementiaNL-OMON53975Amsterdam UMC
招募中
不适用
Quantitative blood-brain barrier permeability and susceptibility mapping for patients with CADASIL and suspected to have CADASICADASIJPRN-UMIN000035081agoya City University40
已完成
不适用
Blood-Brain Barrier permeability quantification in cerebral small vessel disease -- reproducibility of dynamic contrast-enhanced MRICerebral small vessel diseasedisease of the small brain arteries10007963NL-OMON38519Medisch Universitair Ziekenhuis Maastricht20