Effect of Lower Limb Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Plasma Creatine Concentration of the Recipients
研究概览
简要总结
The purpose of this study was to investigate whether lower limb ischaemic preconditioning can improve renal function in patients undergoing living donor kidney transplantation
详细描述
Ischemia reperfusion injury (IRI) induced renal failure after kidney transplantation is a common clinical problem associated with a high morbidity and mortality. To reduce the adverse effects of IRI after organ transplantation various strategies aimed at the different pathophysiological processes of IRI have been investigated. Remote ischemic preconditioning (RIPC) is one such strategy where brief IRI of one organ protects other organs from sustained IRI. Many studies have shown that RIPC protects heart, muscle flaps, stomach, liver, lungs, and kidneys from IRI. RIPC of the limb with a tourniquet is a safe and convenient method of preconditioning organs against IRI. However, the efficacy of RIPC in patients undergoing living donor kidney transplantation need to be established and mechanism of early and late RIPC, such as whether the donor should undergo remote preconditioning or the recipient, need to be investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject capable of giving written informed consent, with end-stage kidney disease, who is a suitable candidate for primary kidney transplantation
- •Living donors
- •Compatible ABO blood type
- •PRA < 20%
排除标准
- •Re-transplant patients
- •Those with peripheral vascular disease affecting the lower limbs
结局指标
主要结局
Plasma Creatine Concentration of the Recipients
时间窗: within the first 3days after the operation
Plasma creatinine concentration before surgery, 1hour, 4hours, 24hours, 48hours and 72hours after the artery unclamping
Urinary Output of the Recipients Postoperatively
时间窗: within the first 3days after the operation
Accumulated urinary output 1hour, 4hours and 24hours after the artery unclamping and the urinary output on the 2nd and 3rd day after the operation
Plasma Concentration of NGAL in the Recipients
时间窗: within the first 24hours after the operation
Plasma concentration of neutrophil gelatinase-associated lipocalin (NGAL) before the operation and 24hours after the artery unclamping
次要结局
- Acute Rejection of Transplanted Kidney(before discharge)
- Delayed Graft Function(before discharge)
- Length of Postoperative Hospital Stay(before discharge)
- Total Costs During the Hospitalization(from the admission to the discharge of the patients)
- Urine Concentration of NAG Preoperatively in Recipients(before operation)
- Urine Concentration of NAG Postoperatively in Recipients(within the first 24hours after the artery unclamping)
- Urine Concentration of RBP Preoperatively in the Recipients(before the operation)
- Urine Concentration of RBP Postoperatively in the Recipients(within the first 24hours after the artery unclamping)
- Plasma Concentration of SOD in the Recipients(within 24hours after the operation)
- Plasma Concentration of MDA in the Recipients(within the first 24hours after the operation)
研究者
Hua Zheng
M.D. Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
Huazhong University of Science and Technology