Autonomic Nervous System Alteration Induce by Sepsis:Assessment and Prognosis Impact
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Septic Shock
- Sponsor
- University Hospital, Grenoble
- Enrollment
- 13
- Locations
- 1
- Primary Endpoint
- Sinusal variability analysis and myocardic fixation of MIBG performed in 48 hours post admission
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Severe sepsis and septic shock are causes of admission in intensive care units.Modification of natriuretic peptid including NT-proBNP and cardiac autonomic nervous system alteration are reported in sepsis shock and severe sepsis and seems to link to patient prognosis admitted to intensive care units.
Detailed Description
Our principal aim is to characterize modulation of cardiac sympathic nervous system in sepsis through the study of sinusal change and myocardiac fixing of MIBG. The second aim is 1)to assess links between alteration of cardiac sympathic nervous system and NT-PRoBNP variations in sepsis and 2)To know prognostic impact in sympathic nervous system compare to NTproBNP.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient over 18 years admitted in intensive care unit and having severe sepsis criteria or septic shock documented or suspected define as Bone Criteria
- •hemodynamically stable situation
- •sinusal rhythm
- •Patient for social security
Exclusion Criteria
- •Patient under guardianship or trusteeship
- •pregnant or lactating women
- •cardiomyopathy known and/or treated or detect in admission
- •electro-systolic process permanent or transitory
- •neurological history or degenerative pathology
- •chronic respiratory insufficiency
- •Chronic renal insufficiency
Outcomes
Primary Outcomes
Sinusal variability analysis and myocardic fixation of MIBG performed in 48 hours post admission
Time Frame: 48 hours post admission
Secondary Outcomes
- plasmatic measure of NT-ProBNP and catecholamine at admission, day 2 and last day of hospitalisation(30 days)